Circular RNA as a Biomarker for Diagnosis, Prognosis and Therapeutic Target in Acute and Chronic Lymphoid Leukemia.

Autor: Abohassan M; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia., Khaleel AQ; Department of Medical Instruments Engineering, Al-Maarif University College, Al Anbar, 31001, Iraq. Abdulrahman.qais@uoa.edu.iq., Pallathadka H; Manipur International University, Imphal, Manipur, India., Kumar A; Department of Life Sciences, School of Sciences, Jain (Deemed-to-be) University, Bengaluru, Karnataka, 560069, India.; Department of Pharmacy, Vivekananda Global University, Jaipur, Rajasthan, 303012, India., Allela OQB; College of Pharmacy, Al-Noor University, Mosul, Iraq., Hjazi A; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia., Pramanik A; School of Applied and Life Sciences, Ivison of Research and Innovation Uttaranchal University, Dehradun, India., Mustafa YF; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq., Hamzah HF; Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq., Mohammed BA; Department of of technical engineering, Al-Hadi University College, Baghdad, 10011, Iraq.
Jazyk: angličtina
Zdroj: Cell biochemistry and biophysics [Cell Biochem Biophys] 2024 Sep; Vol. 82 (3), pp. 1979-1991. Date of Electronic Publication: 2024 Aug 13.
DOI: 10.1007/s12013-024-01404-8
Abstrakt: Circular RNAs (circRNAs) are single-stranded RNAs that have received much attention in recent years. CircRNAs lack a 5' head and a 3' poly-A tail. The structure of this type of RNAs make them resistant to digestion by exonucleases. CircRNAs are expressed in different cells and have various functions. The function of circRNAs is done by sponging miRNAs, changing gene expression, and protein production. The expression of circRNAs changes in different types of cancers, which causes changes in cell growth, proliferation, differentiation, and apoptosis. Changes in the expression of circRNAs can cause the invasion and progression of tumors. Studies have shown that changes in the expression of circRNAs can be seen in acute lymphoid leukemia (ALL) and chronic lymphoid leukemia (CLL). The conducted studies aim to identify circRNAs whose expression has changed in these leukemias and their more precise function so that these circRNAs can be identified as biomarkers, prediction of patient prognosis, and treatment targets for ALL and CLL patients. In this study, we review the studies conducted on the role and function of circRNAs in ALL and CLL patients. The results of the studies show that there is a possibility of using circRNAs as biomarkers in the identification and treatment of patients in the future.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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