The interplay between metal ions and immune cells in glioma: pathways to immune escape.

Autor: Li JW; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China., Mao YM; Department of Thoracic Surgery, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, Jiangsu Province, China., Chen SL; Department of Clinical Lab, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, China., Ye R; School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China., Fei YR; The First Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang Province, China., Li Y; The First Clinical Medical College, Guangxi Medical University, Nanning, Guangxi Province, China., Tong SY; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China., Yang HW; Department of Clinical Laboratory, Suzhou BOE Hospital, Suzhou, Jiangsu Province, China. 344829600@qq.com., He YB; Department of Clinical Lab, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, China. 20173626@zcmu.edu.cn.
Jazyk: angličtina
Zdroj: Discover oncology [Discov Oncol] 2024 Aug 12; Vol. 15 (1), pp. 348. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1007/s12672-024-01229-0
Abstrakt: This review explores the intricate roles of metal ions-iron, copper, zinc, and selenium-in glioma pathogenesis and immune evasion. Dysregulated metal ion metabolism significantly contributes to glioma progression by inducing oxidative stress, promoting angiogenesis, and modulating immune cell functions. Iron accumulation enhances oxidative DNA damage, copper activates hypoxia-inducible factors to stimulate angiogenesis, zinc influences cell proliferation and apoptosis, and selenium modulates the tumor microenvironment through its antioxidant properties. These metal ions also facilitate immune escape by upregulating immune checkpoints and secreting immunosuppressive cytokines. Targeting metal ion pathways with therapeutic strategies such as chelating agents and metalloproteinase inhibitors, particularly in combination with conventional treatments like chemotherapy and immunotherapy, shows promise in improving treatment efficacy and overcoming resistance. Future research should leverage advanced bioinformatics and integrative methodologies to deepen the understanding of metal ion-immune interactions, ultimately identifying novel biomarkers and therapeutic targets to enhance glioma management and patient outcomes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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