Comparison of Metabolic Changes after 6 Months of High-Carbohydrate Diet or High-Fat Diet with Low Dose Streptozotocin Injection in Rats.

Autor: Ivanov EV; Lomonosov Moscow State University, Moscow, Russia. ivanovev102@yandex.ru., Akhmetshina MR; Lomonosov Moscow State University, Moscow, Russia., Gizatulina AR; Lomonosov Moscow State University, Moscow, Russia., Erdiakov AK; Lomonosov Moscow State University, Moscow, Russia., Meinarovich PA; Lomonosov Moscow State University, Moscow, Russia., Gavrilova SA; Lomonosov Moscow State University, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Jul; Vol. 177 (3), pp. 395-400. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1007/s10517-024-06196-8
Abstrakt: We compared 2 models of metabolic syndrome in rats: high-fat diet (58% calories) with single streptozotocin injection at a dose of 25 mg/kg and replacement of water with 20% fructose solution. The model with fructose solution did not cause the main signs of metabolic syndrome over 24 weeks: concentrations of glucose, triglycerides, cholesterol, weight, and BP did not significantly differ from the control group (standard diet). At the same time, single streptozotocin administration was followed by the development of persistent hyperglycemia, hypertriglyceridemia, hypercholesterolemia, and signs of visceral obesity. High-fat diet combined with injection of streptozotocin in a low dose can be considered a more representative model of metabolic syndrome in humans.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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