The Number of Syncytial Knots and the Intensity of VEGF Expression in the Villi of the Monochorionic Diamniotic Placenta in Selective Fetal Growth Restriction.

Autor: Frolova ER; National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I.Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia., Tumanova UN; National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I.Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia., Gladkova KA; National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I.Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia., Khodzhaeva ZS; National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I.Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia., Shchegolev AI; National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I.Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia. patan777@gmail.com.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Jul; Vol. 177 (3), pp. 389-394. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1007/s10517-024-06195-9
Abstrakt: A comparative study was carried out to analyze the number of syncytial knots and the intensity of expression of vascular endothelial growth factor (VEGF) in the villi of the monochorionic diamniotic placenta in pregnancies complicated by the syndrome of selective fetal growth restriction (sFGR). We performed a morphological analysis of 32 monochorionic diamniotic placentas after term delivery which were divided into two groups. The main group included the placentas of 15 puerperas whose pregnancies were complicated by sFGR. The control group included twin placentas of 17 puerperas without signs of sFGR. The number of syncytial knots was determined by histological studies, and the levels of VEGF expression in syncytiotrophoblast and capillary endotheliocytes of the placental villi were determined by immunohistochemical studies. The study showed an increase in the number of syncytial knots in the villi of the placental part of the fetus with sFGR which indicated the development of preplacental hypoxia. A significant increase in the level of VEGF expression in the syncytiotrophoblast and vascular endothelium of the villi should be considered as a manifestation of a compensatory adaptational response to hypoxia, though it is insufficient to prevent the development of sFGR.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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