Organs on chips: fundamentals, bioengineering and applications.

Autor: Awad NK; Physical Chemistry Department, Advanced Materials Technology and Mineral Resources Research Institute, National Research Centre, Dokki, 12422, Cairo, Egypt. awadnrc@gmail.com.
Jazyk: angličtina
Zdroj: Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs [J Artif Organs] 2024 Aug 12. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1007/s10047-024-01460-0
Abstrakt: Human body constitutes unique biological system containing specific fluid mechanics and biomechanics. Traditional cell culture techniques of 2D and 3D do not recapitulate these specific natures of the human system. In addition, they lack the spatiotemporal conditions of representing the cells. Moreover, they do not enable the study of cell-cell interactions in multiple cell culture platforms. Therefore, establishing biological system of dynamic cell culture was of great interest. Organs on chips systems were fabricated proving their concept to mimic specific organs functions. Therefore, it paves the way for validating new drugs and establishes mechanisms of emerging diseases. It has played a key role in validating suitable vaccines for Coronavirus disease (COVID-19). Herein, the concept of organs on chips, fabrication methodology and their applications are discussed.
(© 2024. The Japanese Society for Artificial Organs.)
Databáze: MEDLINE
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