Impact of breast milk on cortical pain response in newborns during the heel prick procedure: a randomized controlled trial.

Autor: Bulut O; Department of Pediatrics, Division of Neonatology, Istanbul Medeniyet University Goztepe Prof. Dr. Suleyman Yalcın City Hospital, Istanbul, Turkey. ozgulbulut@yahoo.com., Topaloglu SC; Department of Pediatrics, Division of Neonatology, Istanbul Medeniyet University Goztepe Prof. Dr. Suleyman Yalcın City Hospital, Istanbul, Turkey., Bulut N; Department of Biostatistics and Medical Informatics, Istanbul Medeniyet University Goztepe Prof. Dr. Suleyman Yalcın City Hospital, Istanbul, Turkey., Hocaoglu M; Department of Obstetrics and Gynecology, Istanbul Medeniyet University Goztepe Prof. Dr. Suleyman Yalcın City Hospital, Istanbul, Turkey., Arslanoglu S; Department of Pediatrics, Division of Neonatology, Istanbul Medeniyet University Goztepe Prof. Dr. Suleyman Yalcın City Hospital, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Nov; Vol. 44 (11), pp. 1675-1681. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1038/s41372-024-02081-4
Abstrakt: Objective: To investigate the effects of breast milk on cortical pain response and behavioral response in newborns during heel-prick procedure.
Study Design: A prospective, randomized controlled trial was conducted on healty-term newborns, undergoing heel blood sampling. Infants were randomly assigned to study group with receive orally 2 ml breast milk (n = 45) or a control group with no intervention (n = 45). A near-infrared spectroscopy device was used to monitor regional cerebral oxygen saturation (rScO 2 ), while neonatal pain expression was assessed by Neonatal Pain, Agitation, and Sedation Scale (N-PASS).
Results: The N-PASS score (p = 0.001) and the crying time (p = 0.017) were significantly lower in the study group compared to the control group. Although the mean rScO 2 values decreased in both groups during the procedure, the percent change in rScO 2 was not significant difference between two groups.
Conclusion: Breast milk administration decreases behavioral responses to a noxious stimulus without reducing the cortical response to pain.
Clinical Trial Registration: This trial was registered under ClinicalTrials.gov identifier no. NCT05961904.
(© 2024. The Author(s).)
Databáze: MEDLINE
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