Soymilk yogurt fermented using Pediococcus pentosaceus TOKAI 759 m improves mice gut microbiota and reduces pro-inflammatory cytokine production.

Autor:	Nakashima Y; Graduate School of Bioscience, Tokai University , Kamimashiki-gun, Kumamoto, Japan.; JSPS Research Fellowship for Young Scientists, Tokyo, Japan., Onuki K; Graduate School of Agriculture, Tokai University , Kamimashiki-gun, Kumamoto, Japan., Hibi T; Graduate School of Bioscience, Tokai University , Kamimashiki-gun, Kumamoto, Japan.; Research Institute of Agriculture, Tokai University, Kumamoto, Japan., Ohno RI; Graduate School of Agriculture, Tokai University , Kamimashiki-gun, Kumamoto, Japan., Sugawa H; Graduate School of Agriculture, Tokai University , Kamimashiki-gun, Kumamoto, Japan., Tominaga Y; Graduate School of Agriculture, Tokai University , Kamimashiki-gun, Kumamoto, Japan., Yasuda S; Graduate School of Bioscience, Tokai University , Kamimashiki-gun, Kumamoto, Japan.; Graduate School of Agriculture, Tokai University , Kamimashiki-gun, Kumamoto, Japan., Kinoshita H; Graduate School of Bioscience, Tokai University , Kamimashiki-gun, Kumamoto, Japan.; Graduate School of Agriculture, Tokai University , Kamimashiki-gun, Kumamoto, Japan.; Research Institute of Agriculture, Tokai University, Kumamoto, Japan.; Probio Co., Ltd , Aso-gun, Kumamoto, Japan.
Jazyk:	angličtina
Zdroj:	Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2024 Oct 22; Vol. 88 (11), pp. 1349-1361.
DOI:	10.1093/bbb/zbae112
Abstrakt:	This study aimed to determine the anti-inflammatory activities and bioactive compounds of soymilk yogurt prepared using Lactiplantibacillus plantarum TOKAI 17 or Pediococcus pentosaceus TOKAI 759 m. Mice were divided into five groups: normal diet (ND), soymilk, soymilk yogurt using L. plantarum TOKAI 17 (SY 17) or P. pentosaceus TOKAI 759 m (SY 759 m), and 0.5 × 109 cells of each starter strain (BC 17 or BC759m). In the SY 759 m group, the serum pro-inflammatory cytokine levels and the cytotoxicity of natural killer cells were attenuated compared to the ND group. In the cecum microbiota, the abundances of butyrate-producing bacteria increased in the SY 759 m and BC 17 groups. Furthermore, SY 759 m metabolites contained high levels of aglycone isoflavone, adenine and showed a significant decrease in CCL-2 and interleukin-6 production in lipopolysaccharide-induced macrophage. In conclusion, soymilk yogurt produced using P. pentosaceus TOKAI 759 m modulates the gut microbiota and can potentially prevent pro-inflammatory cytokine production. (© The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)
Databáze:	MEDLINE
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