Effect of photobiomodulation in an experimental in vitro model of asthma-Copd overlap.

Autor: Guerra MB; Post Graduate Program in Medicine-Biophotonic, University Nove de Julho (UNINOVE), São Paulo, Brazil., Santana KG; Post Graduate Program in Medicine-Biophotonic, University Nove de Julho (UNINOVE), São Paulo, Brazil., Momolli M; Post Graduate Program in Medicine-Biophotonic, University Nove de Julho (UNINOVE), São Paulo, Brazil., Labat R; Post Graduate Program in Medicine-Biophotonic, University Nove de Julho (UNINOVE), São Paulo, Brazil., Chavantes MC; Postgraduate Program in Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil., Zammuner SR; Post Graduate Program in Medicine-Biophotonic, University Nove de Julho (UNINOVE), São Paulo, Brazil.; Postgraduate Program in Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil., Júnior JAS; Post Graduate Program in Medicine-Biophotonic, University Nove de Julho (UNINOVE), São Paulo, Brazil.; Postgraduate Program in Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil., da Palma RK; Universidad de Vic-Universidade Central de Cataluña, UVic, Vic, Spain., Aimbire F; Translational Medicine, Federal University of São Paulo-UNIFESP, São José dos Campos, Brazil., de Oliveira APL; Post Graduate Program in Medicine-Biophotonic, University Nove de Julho (UNINOVE), São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of biophotonics [J Biophotonics] 2024 Aug 12, pp. e202400124. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1002/jbio.202400124
Abstrakt: The objective of the study was to evaluate the effect of photobiomodulation (PBM) with laser on the inflammatory process in an experimental in vitro model of ACO. The groups were: (1) human bronchial epithelial cells (BEAS-2B); (2) BEAS-2B cells treated with dexamethasone; (3) BEAS-2B cells irradiated with laser; (4) BEAS-2B cells stimulated with cigarette smoke extract (CSE) + House Dust Mite (HDM); (5) BEAS-2B cells stimulated with CSE + HDM and treated with dexamethasone; (6) BEAS-2B cells incubated with CSE + HDM and irradiated with laser. After 24 h, cytokines were quantified. There was a reduction in TNF-α, IL-1β, IL-6, IL-4, IL-5, IL-13, IL-17, IL-21, IL-23, and an increase in IL-10 and IFN-γ in cells from the laser-irradiated ACO group compared to only ACO group. With these results, we can suggest that photobiomodulation acts in the modulation of inflammation observed in ACO, and may be a treatment option.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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