The low-density lipoprotein receptor contributes to carotenoid homeostasis by regulating tissue uptake and fecal elimination.

Autor:	Miller AP; Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL, USA., Monroy WC; Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL, USA., Soria G; Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL, USA., Amengual J; Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL, USA; Division of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL, USA. Electronic address: Jaume6@illinois.edu.
Jazyk:	angličtina
Zdroj:	Molecular metabolism [Mol Metab] 2024 Oct; Vol. 88, pp. 102007. Date of Electronic Publication: 2024 Aug 10.
DOI:	10.1016/j.molmet.2024.102007
Abstrakt:	Objective: Carotenoids are lipophilic plant molecules with antioxidant properties. Some carotenoids such as β-carotene also serve as vitamin A precursors, playing a key role in human health. Carotenoids are transported in lipoproteins with other lipids such as cholesterol, however, the mechanisms responsible for carotenoid storage in tissues and their non-enzymatic elimination remain relatively unexplored. The goal of this study was to examine the contribution of the low-density lipoprotein receptor (LDLR) in the bodily distribution and disposal of carotenoids. Methods: We employed mice lacking one or both carotenoid-cleaving enzymes as suitable models for carotenoid accumulation. We examined the contribution of LDLR in carotenoid distribution by crossbreeding these mice with Ldlr-/- mice or overexpressing LDLR in the liver. Results: Our results show that LDLR plays a dual role in carotenoid homeostasis by simultaneously favoring carotenoid storage in the liver and adipose tissue while facilitating their fecal elimination. Conclusions: Our results highlight a novel role of the LDLR in carotenoid homeostasis, and unveil a previously unrecognized disposal pathway for these important bioactive molecules. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Author(s). Published by Elsevier GmbH.. All rights reserved.)
Databáze:	MEDLINE
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