A multi-component paclitaxel -loaded β-elemene nanoemulsion by transferrin modification enhances anti-non-small-cell lung cancer treatment.

Autor: Chen Y; Anhui Provincial Engineering Research Center for Dental Materials and Application, Institute of Synthesis and Application of Medical Materials, School of Pharmacy, Wannan Medical College, Wuhu 241002, China. Electronic address: cyy1206@163.com., Zhang Z; Anhui Provincial Engineering Research Center for Dental Materials and Application, Institute of Synthesis and Application of Medical Materials, School of Pharmacy, Wannan Medical College, Wuhu 241002, China., Xiong R; Anhui Provincial Engineering Research Center for Dental Materials and Application, Institute of Synthesis and Application of Medical Materials, School of Pharmacy, Wannan Medical College, Wuhu 241002, China., Luan M; Anhui Provincial Engineering Research Center for Dental Materials and Application, Institute of Synthesis and Application of Medical Materials, School of Pharmacy, Wannan Medical College, Wuhu 241002, China., Qian Z; The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China., Zhang Q; Anhui Provincial Engineering Research Center for Dental Materials and Application, Institute of Synthesis and Application of Medical Materials, School of Pharmacy, Wannan Medical College, Wuhu 241002, China., Wang S; Anhui Provincial Engineering Research Center for Dental Materials and Application, Institute of Synthesis and Application of Medical Materials, School of Pharmacy, Wannan Medical College, Wuhu 241002, China. Electronic address: wangshaozhen@wnmc.edu.cn.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2024 Sep 30; Vol. 663, pp. 124570. Date of Electronic Publication: 2024 Aug 10.
DOI: 10.1016/j.ijpharm.2024.124570
Abstrakt: A multi-component paclitaxel (PTX) -loaded β-elemene nanoemulsion by transferrin modification (Tf-PE-MEs) was developed to enhance non-small-cell lung cancer (NSCLC) treatment. After transferrin modification, the particle size of Tf-PE-MEs was (14.87 ± 1.84) nm, and the zeta potential was (-10.19 ± 0.870) mV, respectively. In vitro experiments showed that Tf-PE-MEs induced massive apoptosis in A549 cells, indicating that it had significant cytotoxicity to A549 cells. Through transferrin modification, Tf-PE-MEs accumulated at the tumor site efficiently with overexpressed transferrin receptor (TfR) on the surface of A549 cells. This will allow increasing PTX and β-elemene concentration in the target cells, enhancing the therapeutic effect. Compared to PTX alone, Tf-PE-MEs displayed good anti-tumor efficacy and diminished systemic toxicity in vivo studies. With favourable therapeutic potential, this study provides a new strategy for the combined anticancer treatment of non-small cell lung cancer.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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