Unveiling thiol biomarkers: Glutathione and cysteamine.

Autor: Gopika MG; Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana P O, Kollam, Kerala 690525, India., Gopidas S; Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana P O, Kollam, Kerala 690525, India., Jayan GS; Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana P O, Kollam, Kerala 690525, India., Arathy PS; Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana P O, Kollam, Kerala 690525, India., Saraswathyamma B; Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana P O, Kollam, Kerala 690525, India. Electronic address: beenas@am.amrita.edu.
Jazyk: angličtina
Zdroj: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2024 Sep 15; Vol. 563, pp. 119915. Date of Electronic Publication: 2024 Aug 10.
DOI: 10.1016/j.cca.2024.119915
Abstrakt: The physiological and clinical importance of Glutathione and Cysteamine is emphasized by their participation in a range of conditions, such as diabetes, cancer, renal failure, Parkinson's disease, and hypothyroidism. This necessitates the requirement for accessible, expedited, and cost-efficient testing that can facilitate clinical diagnosis and treatment options. This article examines numerous techniques used to detect both glutathione and cysteamine. The discussed methods include electroanalytical techniques such as voltammetry and amperometry, which are examined for their sensitivity and ability to provide real-time analysis. Furthermore, this study investigates the accuracy of gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) in measuring the concentrations of glutathione and cysteamine. Additionally, the potential of new nanotechnology-based methods, such as plasmonic nanoparticles and quantum dots, to improve the sensitivity of detecting glutathione and cysteamine is emphasized.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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