Efficacy of pegylated Graphene oxide quantum dots as a nanoconjugate sustained release metformin delivery system in in vitro insulin resistance model.

Autor: Sarkar K; Department of Zoology, University of Calcutta, Kolkata, India., Chatterjee A; Department of Zoology, University of Calcutta, Kolkata, India., Bankura B; Multidisciplinary Research Unit, Medical College Kolkata, Kolkata, India., Bank S; Department of Zoology, University of Calcutta, Kolkata, India., Paul N; Department of Zoology, University of Calcutta, Kolkata, India., Chatterjee S; Department of Zoology, University of Calcutta, Kolkata, India., Das A; Department of Zoology, University of Calcutta, Kolkata, India., Dutta K; Department of Polymer Science and Technology, University of Calcutta, Kolkata, India., Chakraborty S; Department of Zoology, University of Calcutta, Kolkata, India., De S; Department of Allied Health Sciences, Brainware University, Kolkata, India., Al-Masud AA; Tissue Biobank Section, Research Department, Natural and Health Science Research Center, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia., Khan GA; Department of Clinical Nutrition, College of Applied Medical Sciences, King Faisal University, Al ASHA, KSA., Chattopadhyay D; Department of Polymer Science and Technology, University of Calcutta, Kolkata, India., Das M; Department of Zoology, University of Calcutta, Kolkata, India.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Aug 12; Vol. 19 (8), pp. e0307166. Date of Electronic Publication: 2024 Aug 12 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0307166
Abstrakt: Metformin, the primary therapy for type 2 diabetes mellitus (T2DM), showed limitations such as varying absorption, rapid system clearance, required large amount, resistance, longstanding side effects. Use of Nano formulations for pharmaceuticals is emerging as a viable technique to reduce negative consequences of drug, while simultaneously attaining precise release and targeted distribution. This study developed a Polyethylene Glycol conjugated Graphene Oxide Quantum dots (GOQD-PEG) nanocomposite for the sustained release of metformin. Herein, we evaluated the effectiveness of metformin-loaded nanoconjugate in in vitro insulin resistance model. Results demonstrated drug loaded nanoconjugate successfully restored glucose uptake and reversed insulin resistance in in vitro conditions at reduced dosage compared to free metformin.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Sarkar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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