Antioxidant and Antimicrobial Activities of 4H-Chromene Based Indole-Pyrimidine Hybrids: Synthesis and Molecular Docking Studies.

Autor: Vanga MK; Department of Chemistry, Osmania University, Hyderabad, 500007, Telangana, India., Bhukya R; Department of Chemistry, Osmania University, Hyderabad, 500007, Telangana, India., Thumma V; Department of Sciences and Humanities, Matrusri Engineering College, Hyderabad, 500059, Telangana, India., Tamalapakula V; University College of Technology, Osmania University, Hyderabad, Telangana, 500007, India., Boddu LS; Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Telangana, 502313, India., Manga V; Department of Chemistry, Osmania University, Hyderabad, 500007, Telangana, India.; Telangana Mahila Viswavidyalayam, Hyderabad, Hyderabad, Telangana, 500095, India.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Dec; Vol. 21 (12), pp. e202401583. Date of Electronic Publication: 2024 Oct 10.
DOI: 10.1002/cbdv.202401583
Abstrakt: A series of 4H-Chromene Based Indole-Pyrimidine Hybrids synthesized using simple and efficient multicomponent reaction. The title molecules were evaluated for their invitro antioxidant and antimicrobial activities. Compounds 8 g containing bromo substituted naphthalene displayed potent antioxidant activity with IC 50 value of 1.09±0.34 μM and 1.10±0.36 μM. Compound 10 a, a 4-methylphenyl derivative presented potent activity with antioxidant activity with IC 50 value of 1.29±0.35 μM and 1.43±0.38 μM. Subsequently, compounds 8 a, 8 b, 8 d and 10 g had shown prominent percentage of inhibition and derived effective IC 50 values in comparison to reference drug Ascorbic Acid. The invitro antimicrobial activity carried out against two gram positive and two gram-negative bacteria, and two fungal strains using Ampicillin and Itraconazole as refence drugs. Compound 10 f exhibited exceptional efficacy against all types of bacterial and fungal strains compared to Ampicillin and Itraconazole, compounds 8 e and 8 g showed activity against bacterial strains whereas compound 10 g exhibited the most effective zone of inhibition against fungal strains. The molecular docking study against crystal structure of NADPH oxidase obtained supporting docking scores and showed notable binding interactions such as H-bond and hydrophobic.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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