Chronic Airflow Limitation, Emphysema and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-Aged Population.

Autor: Blomberg A; Umea University, Department of Public Health and Clinical Medicine, Umea, Sweden; anders.blomberg@umu.se., Torén K; University of Gothenburg, Section of Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, Goteborg, Västra Götaland, Sweden.; Sahlgrenska University Hospital, Department of Occupational and Environmental Medicine, Goteborg, Sweden., Liv P; Umeå University, Department of Public Health and Clinical Medicine, Umea, Sweden., Granåsen G; Umeå University, Department of Public Health and Clinical Medicine, Umea, Sweden., Andersson A; Sahlgrenska University Hospital, COPD Center, Department of Respiratory Medicine and Allergology, Goteborg, Sweden.; University of Gothenburg, COPD Center, Deparmtent of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Goteborg, Västra Götaland, Sweden., Behndig A; Umeå University, Department of Public Health and Clinical Medicine, Umea, Sweden., Bergström G; University of Gothenburg, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Goteborg, Västra Götaland, Sweden.; Sahlgrenska University Hospital, Department of Clinical Physiology, Goteborg, Sweden., Brandberg J; Sahlgrenska University Hospital, Department of Radiology, Goteborg, Sweden.; University of Gothenburg, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, Goteborg, Västra Götaland, Sweden., Caidahl K; Karolinska Institute, Department of Clinical Physiology, Stockholm, Stockholm County, Sweden.; Karolinska University Hospital, Department of Clinical Physiology, Stockholm, Sweden.; Sahlgrenska University Hospital, Department of Clinical Physiology, Goteborg, Sweden., Cederlund K; Karolinska Institute, Department of Clinical Science, Intervention and Technology, Stockholm, Sweden., Egesten A; Lund University, Department of Clinical Sciences Lund, Respiratory Medicine, Allergology and Palliative Medicine, Lund, Sweden., Ekström M; Lund University, Respiratory Medicine, Allergology and Palliative Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund, Sweden., Eriksson MJ; Karolinska Institute Department of Molecular Medicine and Surgery, Stockholm, Stockholm, Sweden.; Karolinska University Hospital, Department of Clinical Physiology, Stockholm, Sweden., Hagström E; Uppsala University, Department of Medical Sciences, Cardiology, Uppsala, Sweden.; Uppsala University, Uppsala Clinical Research Center, Uppsala, Sweden., Janson C; Uppsala University, Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala, Sweden., Jernberg T; Karolinska Institute, Department of Clinical Sciences, Danderyd University Hospital, Stockholm, Sweden., Kylhammar D; Linköping University, Department of Health, Medicine and Caring Sciences, and Department of Clinical Physiology and Wallenberg Centre for Molecular Medicine, Linkoping, Sweden., Lind L; Uppsala University, Department of Medical Sciences, Clinical Epidemiology, Uppsala, Sweden., Lindberg A; Umeå University, Department of Public Health and Clinical Medicine, Umea, Sweden., Lindberg E; Uppsala University, Department of Medical Sciences, Respiratory, Allergy and Sleep research, Uppsala, Sweden., Löfdahl CG; Lund University, Respiratory Medicine, Allergology and Palliative Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund, Sweden., Malinovschi A; Uppsala University, Department of Medical Sciences, Clinical Physiology, Uppsala, Sweden., Mannila M; Karolinska University Hospital, Department of Cardiology and Department of Clinical Genetics, Stockholm, Sweden., Nilsson LT; Umeå University, Department of Public Health and Clinical Medicine, Umea, Sweden., Olin AC; University of Gothenburg, Section of Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, Goteborg, Västra Götaland, Sweden., Persson A; Linköping University, CMIV Centre of Medical Image Science and Visualization, Linkoping, Östergötland, Sweden.; Linköping University, Department of Radiology and Department of Health, Medicine and Caring Sciences, Linkoping, Östergötland, Sweden.; Karolinska Institute, Department of Clinical Sciences, Huddinge University Hospital, Stockholm, Sweden., Persson HL; Linköping University, Department of Health, Medicine and Caring Sciences and Department of Respiratory Medicine, Linkoping, Östergötland, Sweden., Rosengren A; University of Gothenburg, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Goteborg, Västra Götaland, Sweden.; Sahlgrenska University Hospital, Department of Medicine, Geriatrics and Emergency Medicine, Östra Hospital, Goteborg, Sweden., Sundström J; Uppsala University Department of Medical Sciences, Uppsala, Sweden.; The George Institute for Global Health, Sydney, New South Wales, Australia., Swahn E; Linköping University, Department of Cardiology and Department of Health, Medicine and Caring Sciences, Linkoping, Östergötland, Sweden., Söderberg S; Umeå University, Department of Public Health and Clinical Medicine, Umea, Sweden., Vikgren J; Sahlgrenska University Hospital, Department of Radiology, Goteborg, Sweden.; University of Gothenburg, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, Goteborg, Västra Götaland, Sweden., Wollmer P; Lund University, Department of Translational Medicine, Lund, Sweden., Östgren CJ; Linköping University, Department of Health, Medicine and Caring Sciences, Linkoping, Sweden.; Linköping University, CMIV Center for Image Science and Visualization, Linkoping, Östergötland, Sweden., Engvall J; Linköping University, Department of Health, Medicine and Caring Sciences, and Department of Clinical Physiology, Linkoping, Sweden.; Linköping University, CMIV Center for Image Science and Visualization, Linkoping, Östergötland, Sweden., Sköld CM; Karolinska University Hospital, Department of Respiratory Medicine and Allergy, Stockholm, Sweden.; Karolinska Institute, Respiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: Annals of the American Thoracic Society [Ann Am Thorac Soc] 2024 Aug 12. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1513/AnnalsATS.202402-122OC
Abstrakt: Rationale: Chronic obstructive pulmonary disease (COPD) includes respiratory symptoms and chronic airflow limitation (CAL). In some cases, emphysema and impaired diffusing capacity for carbon monoxide (DLCO) are present, but characteristics and symptoms vary with smoking exposure.
Objectives: To study the prevalence of CAL, emphysema and impaired DLCO in relation to smoking and respiratory symptoms in a middle-aged population.
Methods: We investigated 28,746 randomly invited individuals (52% women) aged 50-64 years across six Swedish sites. We performed spirometry, DLCO, high-resolution computed tomography (HRCT) and asked for smoking habits and respiratory symptoms. CAL was defined as post-bronchodilator forced expiratory volume in 1 second divided by forced expiratory volume (FEV1/FVC)<0.7.
Results: The overall prevalence was for CAL 8.8%, for impaired DLCO (DLCOConclusions: In this large population-based study of middle-aged people, CAL and impaired DLCO were associated with common respiratory symptoms. Self-reported asthma was not associated with CAL in never-smokers. Our findings suggest that CAL in never-smokers signifies a separate clinical phenotype that may be monitored and, possibly, treated differently from smoking-related COPD. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
Databáze: MEDLINE
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