Exercise Enhances Anti-contractile Effects of PVAT Through Endogenous H 2 S in High-Fat Diet-Induced Obesity Hypertension.

Autor: Wang C; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China., Shu L; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China., Cheng R; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China., Yan M; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China., Liang W; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China., Zhou J; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China., Shi N; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China., Chen L; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China., Peng L; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China., Huang J; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China.; Scientific Research Center, Guangzhou Sport University, Guangzhou, China., Hu M; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China. minhu@gzsport.edu.cn., Liao J; Guangdong Provincial Key Laboratory of Sports and Health Promotion, Guangzhou Sport University, Tianhe District, 1268 Guangzhou Avenue Middle, Guangzhou, 510500, No, China. liaojw@gzsport.edu.cn.
Jazyk: angličtina
Zdroj: Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2024 Aug 12. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1007/s10557-024-07612-x
Abstrakt: Purpose: Hydrogen sulfide (H 2 S) secreted by perivascular adipose tissue (PVAT) is a critical vasodilator, which might be involved during the pathogenesis of hypertension. The present study aimed to investigate the exact role of H 2 S on the regulation of PVAT anti-contraction by long-term exercise in obesity hypertension.
Methods: After the establishment of obesity hypertension (24 weeks) through a high-fat diet, male Sprague-Dawley rats were randomly assigned to control group (HC), exercise group (HE), cystathionine γ-lyase (CSE) blocking group (HCB), and exercise combined with CSE blocking group (HEB). Exercise and CSE inhibitor regimens were performed throughout 13 weeks.
Results: After 13 weeks of intervention, blood pressure was significantly decreased by long-term exercise (HC vs. HE, P < 0.05) but not by exercise combined with the CSE inhibitor regimen. Meanwhile, the CSE inhibitor significantly blocked the production of H 2 S in PVAT even after exercise (HE vs. HEB, P < 0.05). Furthermore, long-term exercise altered the expressions of voltage-dependent K + (K v ) channel subunits 7 (KCNQs), which were diminished by CSE inhibition in mesenteric arteries. As for vascular tension assessment, after incubation with or without KCNQ opener (retigabine), the anti-contractile effect of PVAT (with or without transferred bath solution of PVAT) was significantly enhanced by long-term exercise and eliminated by the CSE inhibitor regimen (P < 0.05); KCNQ inhibitor (XE991) blunted this effect except for HE.
Conclusions: These results collectively suggest that endogenous H 2 S is a strong regulator of the anti-contractile effect of PVAT in obesity hypertension by long-term exercise, and KCNQ in the resistance artery might be involved during this process but not the only target channel mediated by H 2 S.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: