Association between alcohol flushing syndrome and cancer: A systematic review and meta-analysis.

Autor: Sim W; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Pan JT; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chua CWX; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Fong KY; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Wong SH; Centre for Microbiome Medicine, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, Singapore., Lee B; Centre for Biomedical Informatics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Singapore Immunology Network, Agency of Science Technology and Research, Singapore.; Infectious Disease Labs, Agency for Science, Technology and Research, Singapore., Oon HH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; National Skin Centre and Skin Research Institute of Singapore, Singapore.
Jazyk: angličtina
Zdroj: Annals of the Academy of Medicine, Singapore [Ann Acad Med Singap] 2024 Jul 30; Vol. 53 (7), pp. 420-434. Date of Electronic Publication: 2024 Jul 30.
DOI: 10.47102/annals-acadmedsg.2023351
Abstrakt: Introduction: Alcohol flushing syndrome (AFS) is experienced by up to 46% of East Asians. This study aimed to review the risk of cancers in AFS patients, elucidate an exposure-response relationship, and understand risk associated with alcohol intake and cancer.
Method: An electronic database search of PubMed, Embase, Scopus and Cochrane Library was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Observational studies on AFS' effects and all cancers risk were included. Studies including patients with existing malignancy were excluded. Dichotomous variables were pooled using the Mantel-Haenszel method with a random effects model. Sensitivity and subgroup analyses were performed. PROSPERO (CRD42023392916) protocol was followed.
Results: A total of 18 articles were included in the final analysis with a total of 387,521 participants. AFS was associated with an increased risk of all cancers (odds ratio [OR] 1.19, 95% confidence interval [CI] 1.06-1.34), esophageal squamous cell carcinoma (OR 1.47, 95% CI 1.05-2.05) and gastric adenocarci-noma (OR 1.40, 95% CI 1.14-1.72). Men with AFS exhibited an increased risk of all cancers (OR 1.34, 95% CI 1.13-1.59). However, this was not observed in women. All cancers risk was associated with AFS in those who consumed drink (i.e. consumed alcohol) more than 200 g of pure ethanol/week (OR 1.68, 95% CI 1.20-2.37) but not those who consumed less than 200 g of pure ethanol/week (OR 1.27, 95% CI 0.90-1.79) or non-drinkers (OR 0.99, 95% CI 0.67-1.47).
Conclusion: AFS is associated with an increased risk of all cancers, particularly esophageal squamous cell carcinoma and gastric adenocarcinoma.
Databáze: MEDLINE
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