Metabolism of 2,4-D in plants: comparative analysis of metabolic detoxification pathways in tolerant crops and resistant weeds.

Autor: Torra J; Department of Agricultural and Forest Sciences and Engineering, University of Lleida - Agrotecnio CERCA Center, Lleida, Spain., Alcántara-de la Cruz R; Departmento de Agronomia, Universidade Federal de Viçosa, Viçosa, Brazil., de Figueiredo MRA; Department of Agricultural Biology, Colorado State University, Fort Collins, CO, USA., Gaines TA; Department of Agricultural Biology, Colorado State University, Fort Collins, CO, USA., Jugulam M; Department of Agronomy, Kansas State University, Manhattan, KS, USA., Merotto A Jr; Department of Crop Science, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Palma-Bautista C; Departamento de Parasitología Agrícola, Universidad Autónoma Chapingo, Texcoco, Mexico., Rojano-Delgado AM; Department of Agricultural Chemistry and Soil Science, University of Córdoba, Córdoba, Spain., Riechers DE; Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Jazyk: angličtina
Zdroj: Pest management science [Pest Manag Sci] 2024 Dec; Vol. 80 (12), pp. 6041-6052. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1002/ps.8373
Abstrakt: The commercialization of 2,4-D (2,4-dichlorophenoxyacetic acid) latifolicide in 1945 marked the beginning of the selective herbicide market, with this active ingredient playing a pivotal role among commercial herbicides due to the natural tolerance of monocots compared with dicots. Due to its intricate mode of action, involving interactions within endogenous auxin signaling networks, 2,4-D was initially considered a low-risk herbicide to evolve weed resistance. However, the intensification of 2,4-D use has contributed to the emergence of 2,4-D-resistant broadleaf weeds, challenging earlier beliefs. This review explores 2,4-D tolerance in crops and evolved resistance in weeds, emphasizing an in-depth understanding of 2,4-D metabolic detoxification. Nine confirmed 2,4-D-resistant weed species, driven by rapid metabolism, highlight cytochrome P450 monooxygenases in Phase I and glycosyltransferases in Phase II as key enzymes. Resistance to 2,4-D may also involve impaired translocation associated with mutations in auxin/indole-3-acetic acid (Aux/IAA) co-receptor genes. Moreover, temperature variations affect 2,4-D efficacy, with high temperatures increasing herbicide metabolism rates and reducing weed control, while drought stress did not affect 2,4-D efficacy. Research on 2,4-D resistance has primarily focused on non-target-site resistance (NTSR) mechanisms, including 2,4-D metabolic detoxification, with limited exploration of the inheritance and genetic basis underlying these traits. Resistance to 2,4-D in weeds is typically governed by a single gene, either dominant or incompletely dominant, raising questions about gain-of-function or loss-of-function mutations that confer resistance. Future research should unravel the physiological and molecular-genetic basis of 2,4-D NTSR, exploring potential cross-resistance patterns and assessing fitness costs that may affect future evolution of auxin-resistant weeds. © 2024 Society of Chemical Industry.
(© 2024 Society of Chemical Industry.)
Databáze: MEDLINE
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