Controlled Transdermal Delivery of Dexamethasone for Pain Management via Photochemically 3D-Printed Bioresorbable Microneedle Arrays.

Autor: Bahnick AJ; Department of Chemistry, Duke University, Durham, NC, 27708, USA., Dziewior CS; Department of Chemistry, Duke University, Durham, NC, 27708, USA., Li Y; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC, 27710, USA., Chou A; Department of Chemistry, Duke University, Durham, NC, 27708, USA.; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA., Segal M; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA., Augustine EK; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA., Ji RR; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC, 27710, USA., Becker ML; Department of Chemistry, Duke University, Durham, NC, 27708, USA.; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708, USA.; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.; Department of Orthopaedic Surgery, Duke University, Durham, NC, 27710, USA.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Dec; Vol. 13 (31), pp. e2402113. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1002/adhm.202402113
Abstrakt: Microneedle array patches (MAPs) are extensively studied for transdermal drug delivery. Additive manufacturing enables precise control over MAP customization and rapid fabrication. However, the scope of 3D-printable, bioresorbable materials is limited. Dexamethasone (DXM) is widely used to manage inflammation and pain, but its application is limited by systemic side effects. Thus, it is crucial to achieve high local drug concentrations while maintaining low serum levels. Here, poly(propylene fumarate-co-propylene succinate) oligomers are fabricated into DXM-loaded, bioresorbable MAPs via continuous liquid interface production 3D printing. Thiol-ene click chemistry yields MAPs with tailorable mechanical and degradation properties. DXM-loaded MAPs exhibit controlled elution of drug in vitro. Transdermal application of DXM-loaded MAPs in a murine tibial fracture model leads to substantial relief of postoperative pain. Pharmacokinetic analysis shows that MAP administration is able to control pain at a significantly lower dose than intravenous administration. This work expands the material properties of 3D-printed poly(propylene fumarate-co-propylene succinate) copolyesters and their use in drug delivery applications.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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