Associations of circulating T-cell subsets in carotid artery stiffness: the Multi-Ethnic Study of Atherosclerosis.

Autor: DeConne TM; Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC., Buzkova P; Department of Biostatistics, University of Washington, Seattle, WA, USA., Pewowaruk R; Ryan Pewowaruk Research Consulting., Delaney JA; Departments of Medicine and Epidemiology, University of Washington, Seattle, WA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, WA., Tracy RP; Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT., Doyle MF; Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT., Sitlani CM; Department of Medicine, University of Washington, Seattle, WA., Landay AL; Geriatrics Department of Internal Medicine, University of Texas Medical Brach at Galveston, Galveston, TX., Huber SA; Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT., Hughes TM; Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC., Bertoni AG; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC., Gepner AD; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.; William S. Middleton Memorial Veterans Hospital and Clinics, Madison, WI., Olson NC; Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT., Ding J; Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.
Jazyk: angličtina
Zdroj: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jul 31. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1101/2024.07.29.24311196
Abstrakt: Background: Arterial stiffness measured by total pulse wave velocity (T-PWV) is associated with increased risk of multiple age-related diseases. T-PWV can be described by structural (S-PWV) and load-dependent (LD-PWV) arterial stiffening. T-cells have been associated with arterial remodeling, blood pressure, and arterial stiffness in humans and animals; however, it is unknown whether T-cells are related to S-PWV or LD-PWV. Therefore, we evaluated the cross-sectional associations of peripheral T-cell subpopulations with T-PWV, S-PWV, and LD-PWV stiffness.
Methods: Peripheral blood T-cells were characterized using flow cytometry and the carotid artery was measured using B-mode ultrasound to calculate T-PWV at the baseline examination in a subset of the Multi-Ethnic Study of Atherosclerosis (MESA, n=1,984). A participant-specific exponential model was used to calculate S-PWV and LD-PWV based on elastic modulus and blood pressure gradients. The associations between five primary (p-significance<0.01) and twenty-five exploratory (p-significance<0.05) immune cell subpopulations, per 1-SD increment, and arterial stiffness measures were assessed using adjusted, linear regressions.
Results: For the primary analysis, higher CD4 + CD28 - CD57 + T-cells were associated with higher LD-PWV (β=0.04 m/s, p<0.01) after adjusting for co-variates. For the exploratory analysis, T-cell subpopulations that commonly shift with aging towards memory and differentiated/immunosenescent phenotypes were associated with greater T-PWV, S-PWV, and LD-PWV after adjusting for co-variates.
Conclusions: In this cross-sectional study, several T-cell subpopulations commonly associated with aging were related with measures of arterial stiffness. Longitudinal studies that examine changes in T-cell subpopulations and measures of arterial stiffness are warranted.
Databáze: MEDLINE