[ 18 F]FSPG-PET provides an early marker of radiotherapy response in head and neck squamous cell cancer.

Autor: Sambasivan K; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; Department of Clinical Oncology, Guy's and St Thomas' NHS Foundation Trust, London, UK., Tyrrell WE; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Farooq R; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Mynerich J; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Edwards RS; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Tanc M; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Urbano TG; Department of Clinical Oncology, Guy's and St Thomas' NHS Foundation Trust, London, UK.; Faculty of Dentistry, Oral & Craniofacial Sciences and School of Cancer & Pharmaceutical Sciences, King's College London, London, UK., Witney TH; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Jazyk: angličtina
Zdroj: Npj imaging [Npj Imaging] 2024; Vol. 2 (1), pp. 28. Date of Electronic Publication: 2024 Aug 09.
DOI: 10.1038/s44303-024-00038-y
Abstrakt: The ability to image early treatment response to radiotherapy in head and neck squamous cell carcinoma (HNSCC) will enable the identification of radioresistant tumor volumes suitable for treatment intensification. Here, we propose the system x c - radiotracer (4 S )-4-(3-[ 18 F]fluoropropyl)-L-glutamate ([ 18 F]FSPG) as a non-invasive method to monitor radiation response in HNSCC. We assessed temporal changes in cell death, antioxidant status, and [ 18 F]FSPG retention following a single dose of 10 Gy irradiation in FaDU HNSCC cells. Next, using a fractionated course of radiotherapy, we assessed tumor volume changes and performed [ 18 F]FSPG-PET imaging in FaDU-bearing mouse xenografts, followed by ex vivo response assessment. In cells, 10 Gy irradiation reduced [ 18 F]FSPG retention, coinciding with the induction of apoptosis and the production of reactive oxygen species. In vivo, [ 18 F]FSPG tumor retention was halved seven days after the start of treatment, which preceded radiotherapy-induced tumor shrinkage, thereby confirming [ 18 F]FSPG-PET as an early and sensitive marker of radiation response.
Competing Interests: Competing interestsT.H.W. is the Editor-in-Chief of npj Imaging. He was blinded to this manuscript's editorial and peer review process. All other authors declare no competing financial or non-financial interests.
(© The Author(s) 2024.)
Databáze: MEDLINE
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