Toluene exposure and changes in platelet count: a narrative review.

Autor:	da Silva GMR; Faculdade de Medicina, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Slawka E; Faculdade de Medicina, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Santos ASE; Instituto de Estudos em Saúde Coletiva, UFRJ, Rio de Janeiro, RJ, Brazil., Vianna ADS; Instituto de Estudos em Saúde Coletiva, UFRJ, Rio de Janeiro, RJ, Brazil.
Jazyk:	angličtina
Zdroj:	Revista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMT [Rev Bras Med Trab] 2024 Feb 16; Vol. 21 (4), pp. e2021896. Date of Electronic Publication: 2024 Feb 16 (Print Publication: 2023).
DOI:	10.47626/1679-4435-2021-896
Abstrakt:	Toluene is a widely used solvent whose many toxic effects include neurological and hematological damage. This study reviewed evidence about the effects of toluene exposure on platelet count in humans. Three electronic databases and a digital library of theses and dissertations were searched using a specific strategy, yielding 64 articles, of which 14 were selected. These studies assessed a total of 15,759 participants, including 13,297 exposed individuals, mainly women exposed in an environmental setting. The major findings were: (1) conflicting results (positive, inverse, or no association), (2) cross-contamination with other substances, which impaired assessment of the relationship, and (3) a lack of studies. Thus, further research is needed on this topic, especially toluene exposure in isolation from associated substances. Competing Interests: Conflicts of interest: None
Databáze:	MEDLINE
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