Developing a Common Global Baseline for Nucleic Acid Synthesis Screening.
| Autor: | Wheeler NE; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom., Carter SR; Science Policy Consulting LLC, Arlington, Virginia, USA., Alexanian T; International Biosecurity and Biosafety Initiative for Science (IBBIS), Geneva, Switzerland., Isaac C; Nuclear Threat Initiative, Washington, DC, USA., Yassif J; Nuclear Threat Initiative, Washington, DC, USA., Millet P; International Biosecurity and Biosafety Initiative for Science (IBBIS), Geneva, Switzerland. |
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| Jazyk: | angličtina |
| Zdroj: | Applied biosafety : journal of the American Biological Safety Association [Appl Biosaf] 2024 Jun 20; Vol. 29 (2), pp. 71-78. Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024). |
| DOI: | 10.1089/apb.2023.0034 |
| Abstrakt: | Introduction: Nucleic acid synthesis is a powerful tool that has revolutionized the life sciences. However, the misuse of synthetic nucleic acids could pose a serious threat to public health and safety. There is a need for international standards for nucleic acid synthesis screening to help prevent the misuse of this technology. Methods: We outline current barriers to the adoption of screening, which include the cost of developing screening tools and resources, adapting to existing commercial practices, internationalizing screening, and adapting screening to benchtop nucleic acid synthesis devices. To address these challenges, we then introduce the Common Mechanism for DNA Synthesis Screening, which was developed in consultation with a technical consortium of experts in DNA synthesis, synthetic biology, biosecurity, and policy, with the aim of addressing current barriers. The Common Mechanism software uses a variety of methods to identify sequences of concern, identify taxonomic best matches to regulated pathogens, and identify benign genes that can be cleared for synthesis. Finally, we describe outstanding challenges in the development of screening practices. Results: The Common Mechanism is a step toward ensuring the safe and responsible use of synthetic nucleic acids. It provides a baseline capability that overcomes challenges to nucleic acid synthesis screening and provides a solution for broader international adoption of screening practices. Conclusion: The Common Mechanism is a valuable tool for preventing the misuse of synthetic nucleic acids. It is a critical step toward ensuring the safe and responsible use of this powerful technology. (© Nicole E. Wheeler et al., 2024; Published by Mary Ann Liebert, Inc.) |
| Databáze: | MEDLINE |
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