Emerging Therapeutic Strategies in Cardiovascular Diseases.

Autor:	Singh R; Internal Medicine, Government Medical College Amritsar, Amritsar, IND., Chandi SK; Internal Medicine, Government Medical College Amritsar, Amritsar, IND., Sran S; Internal Medicine, Sri Guru Ram Das University of Health Sciences and Research, Amritsar, IND., Aulakh SK; Internal Medicine, Sri Guru Ram Das University of Health Sciences and Research, Amritsar, IND., Nijjar GS; Medicine, Government Medical College Amritsar, Amritsar, IND., Singh K; Medicine, Government Medical College Amritsar, Amritsar, IND., Singh S; Medicine, Government Medical College Amritsar, Amritsar, IND., Tanvir F; Medicine, Government Medical College Amritsar, Amritsar, IND., Kaur Y; Medicine, Government Medical College Amritsar, Amritsar, IND., Sandhu APS; Medicine, Sri Guru Ram Das University of Health Sciences and Research, Amritsar, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 12; Vol. 16 (7), pp. e64388. Date of Electronic Publication: 2024 Jul 12 (Print Publication: 2024).
DOI:	10.7759/cureus.64388
Abstrakt:	Cardiovascular diseases (CVDs), including ischemic heart disease and stroke, are the leading cause of mortality worldwide, causing nearly 20 million deaths annually. Traditional therapies, while effective, have not curbed the rising prevalence of CVDs driven by aging populations and lifestyle factors. This review highlights innovative therapeutic strategies that show promise in improving patient outcomes and transforming cardiovascular care. Emerging pharmacological treatments, such as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and sodium-glucose co-transporter 2 (SGLT2) inhibitors, introduce novel mechanisms to complement existing therapies, significantly reducing cardiovascular events and mortality. These advancements emphasize the necessity of ongoing clinical trials and research to discover new therapeutic targets. Advanced biological therapies, including gene therapy, stem cell therapy, and RNA-based treatments, offer groundbreaking potential for repairing and regenerating damaged cardiovascular tissues. Despite being in various stages of clinical validation, early results are promising, suggesting these therapies could fundamentally change the CVD treatment landscape. Innovative medical devices and technologies, such as implantable devices, minimally invasive procedures, and wearable technology, are revolutionizing CVD management. These advancements facilitate early diagnosis, continuous monitoring, and effective treatment, driving care out of hospitals and into homes, improving patient outcomes and reducing healthcare costs. Personalized medicine, driven by genetic profiling and biomarker identification, allows for tailored therapies that enhance treatment efficacy and minimize adverse effects. However, the adoption of these emerging therapies faces significant challenges, including regulatory hurdles, cost and accessibility issues, and ethical considerations. Addressing these barriers and fostering interdisciplinary collaboration are crucial for accelerating the development and implementation of innovative treatments. Integrating emerging therapeutic strategies in cardiovascular care holds immense potential to transform CVD management. By prioritizing future research and overcoming existing challenges, a new era of personalized, effective, and accessible cardiovascular care can be achieved. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Singh et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu