Effect of C 60 Fullerene on Muscle Injury-Induced Rhabdomyolysis and Associated Acute Renal Failure.
| Autor: | Prylutskyy Y; ESC 'institute of Biology and Medicine', Taras Shevchenko National University of Kyiv, Kyiv, Ukraine., Nozdrenko D; ESC 'institute of Biology and Medicine', Taras Shevchenko National University of Kyiv, Kyiv, Ukraine., Omelchuk O; Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University, Lutsk, Ukraine., Prylutska S; Faculty of Plant Protection, Biotechnology and Ecology, National University of Life and Environmental Science of Ukraine, Kyiv, Ukraine., Motuziuk O; ESC 'institute of Biology and Medicine', Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.; Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University, Lutsk, Ukraine., Soroсa V; ESC 'institute of Biology and Medicine', Taras Shevchenko National University of Kyiv, Kyiv, Ukraine., Vareniuk I; ESC 'institute of Biology and Medicine', Taras Shevchenko National University of Kyiv, Kyiv, Ukraine., Stetska V; ESC 'institute of Biology and Medicine', Taras Shevchenko National University of Kyiv, Kyiv, Ukraine., Bogutska K; ESC 'institute of Biology and Medicine', Taras Shevchenko National University of Kyiv, Kyiv, Ukraine., Ritter U; Institute of Chemistry and Biotechnology, Technical University of Ilmenau, Ilmenau, Germany., Piosik J; Intercollegiate Faculty of Biotechnology, University of Gdansk, Gdańsk, Poland. |
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| Jazyk: | angličtina |
| Zdroj: | International journal of nanomedicine [Int J Nanomedicine] 2024 Aug 06; Vol. 19, pp. 8043-8058. Date of Electronic Publication: 2024 Aug 06 (Print Publication: 2024). |
| DOI: | 10.2147/IJN.S468013 |
| Abstrakt: | Introduction: Rhabdomyolysis, as an acute stage of myopathy, causes kidney damage. It is known that this pathology is caused by the accumulation of muscle breakdown products and is associated with oxidative stress. Therefore, the present study evaluated the effect of intraperitoneal administration (dose 1 mg/kg) of water-soluble C Methods: Using tensometry, biochemical and histopathological analyses, the biomechanical parameters of muscle soleus contraction (contraction force and integrated muscle power), biochemical indicators of rat blood (concentrations of creatinine, creatine phosphokinase, urea and hydrogen peroxide, catalase and superoxide dismutase activity), glomerular filtration rate and fractional sodium excretion value, as well as pathohistological and morphometric features of muscle and kidney damages in rats on days 1, 3, 6 and 9 after the initiation of the injury were studied. Results: Positive changes in biomechanical and biochemical parameters were found during the experiment by about 27-30 ± 2%, as well as a decrease in pathohistological and morphometric features of muscle and kidney damages in rats treated with water-soluble C Conclusion: These findings indicate the potential application of water-soluble C Competing Interests: The authors declare no conflicts of interest in this work. (© 2024 Prylutskyy et al.) |
| Databáze: | MEDLINE |
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