The role of CBL family ubiquitin ligases in cancer progression and therapeutic strategies.

Autor:	Ren J; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China.; School of Pharmacy, Dalian Medical University, Dalian, China., Lv L; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China., Tao X; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China., Zhai X; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China., Chen X; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China., Yu H; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China.; School of Pharmacy, Dalian Medical University, Dalian, China., Zhao X; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China.; School of Pharmacy, Dalian Medical University, Dalian, China., Kong X; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China.; School of Pharmacy, Dalian Medical University, Dalian, China., Yu Z; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China., Dong D; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, China., Liu J; Stem Cell Clinical Research Center, National Joint Engineering Laboratory, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2024 Jul 26; Vol. 15, pp. 1432545. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2024).
DOI:	10.3389/fphar.2024.1432545
Abstrakt:	The CBL (Casitas B-lineage lymphoma) family, as a class of ubiquitin ligases, can regulate signal transduction and activate receptor tyrosine kinases through various tyrosine kinase-dependent pathways. There are three members of the family: c-CBL, CBL-b, and CBL-c. Numerous studies have demonstrated the important role of CBL in various cellular pathways, particularly those involved in the occurrence and progression of cancer, hematopoietic development, and regulation of T cell receptors. Therefore, the purpose of this review is to comprehensively summarize the function and regulatory role of CBL family proteins in different human tumors, as well as the progress of drug research targeting CBL family, so as to provide a broader clinical measurement strategy for the treatment of tumors. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Ren, Lv, Tao, Zhai, Chen, Yu, Zhao, Kong, Yu, Dong and Liu.)
Databáze:	MEDLINE
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