Anaerobic bacteria in chronic wounds: Roles in disease, infection and treatment failure.

Autor: Coluccio A; Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA., Lopez Palomera F; Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA., Spero MA; Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA.
Jazyk: angličtina
Zdroj: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society [Wound Repair Regen] 2024 Aug 12. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1111/wrr.13208
Abstrakt: Infection is among the most common factors that impede wound healing, yet standard treatments routinely fail to resolve chronic wound infections. The chronic wound environment is largely hypoxic/anoxic, and wounds are predominantly colonised by facultative and obligate anaerobic bacteria. Oxygen (O 2 ) limitation is an underappreciated driver of microbiota composition and behaviour in chronic wounds. In this perspective article, we examine how anaerobic bacteria and their distinct physiologies support persistent, antibiotic-recalcitrant infections. We describe the anaerobic energy metabolisms bacteria rely on for long-term survival in the wound environment, and why many antibiotics become less effective under hypoxic conditions. We also discuss obligate anaerobes, which are among the most prevalent taxa to colonise chronic wounds, yet their potential roles in influencing the microbial community and wound healing have been overlooked. All of the most common obligate anaerobes found in chronic wounds are opportunistic pathogens. We consider how these organisms persist in the wound environment and interface with host physiology to hinder wound healing processes or promote chronic inflammation. Finally, we apply our understanding of anaerobic physiologies to evaluate current treatment practices and to propose new strategies for treating chronic wound infections.
(© 2024 The Wound Healing Society.)
Databáze: MEDLINE
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