New Horizons in Antiretroviral Drug Delivery Systems for HIV Management

Autor:	dos Santos KA; Center for Quality Control of Medicines and Related Products, Federal University of Pernambuco, Recife, PE, Brazil; Program of Scientific Innovation, Federal University of Pernambuco, Recife, PE, Brazil;, de Carvalho Moreira LMC; Center for Quality Control of Medicines and Related Products, Federal University of Pernambuco, Recife, PE, Brazil; Program of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, PE, Brazil, Soares-Sobrinho JL; Center for Quality Control of Medicines and Related Products, Federal University of Pernambuco, Recife, PE, Brazil; Program of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, PE, Brazil, de La Roca Soares MF; Center for Quality Control of Medicines and Related Products, Federal University of Pernambuco, Recife, PE, Brazil; Program of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, PE, Brazil
Jazyk:	angličtina
Zdroj:	Current medicinal chemistry [Curr Med Chem] 2024 Aug 09. Date of Electronic Publication: 2024 Aug 09.
DOI:	10.2174/0109298673306606240802111136
Abstrakt:	Introduction: Human Immunodeficiency Virus (HIV) infection is still a major global problem, whose drug treatment consists of prophylactic prevention and antiretroviral combination therapy for better pharmacological efficacy and control of the circulating virus. However, there are still pharmacological problems that need to be overcome, such as low aqueous solubility of drugs, toxicity, and low patient adherence. Drug delivery technologies can be used to overcome these barriers. Objective: This review summarized the latest drug delivery systems for HIV treatment. Initially, an overview of the current therapy was presented, along with the problems it presents. Then, the latest drug delivery systems used to overcome the challenges imposed in conventional HIV therapy were discussed. Conclusion: This review examines innovative approaches for HIV treatment, where various drug delivery systems have shown significant advantages, such as high drug encapsulation, improved solubility, and enhanced bioavailability both in vitro and in vivo. Strategies like cyclodextrins, solid dispersions, microneedles, and nanoparticles are explored to address challenges in drug solubility, bioavailability, and administration routes. Despite progress, obstacles like limited clinical trials and industrial scalability hinder the widespread adoption of these formulations, emphasizing the need for further research and collaboration to optimize and ensure accessibility of innovative HIV therapies, mainly in regions where access to HIV treatment is scarce and remains a challenge. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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