Endoscopic duodenal-jejunal bypass liner treatment of moderate obstructive sleep apnoea-A pilot study.

Autor: Yadagiri M; Diabetes Department, Sandwell & West Birmingham NHS Trust, Birmingham, UK., Kinney FY; Research and Development, Sandwell & West Birmingham NHS Trust, Birmingham, UK., Ashman N; Respiratory Physiology, Sandwell & West Birmingham NHS Trust, City Hospital, Birmingham, UK., Bleasdale JP; Anaesthetics Department, Sandwell & West Birmingham NHS Trust, City Hospital, Birmingham, UK., Fogden EN; Gastroenterology Department, Sandwell & West Birmingham NHS Trust, City Hospital, Birmingham, UK., Anderson MR; Gastroenterology Department, Sandwell & West Birmingham NHS Trust, City Hospital, Birmingham, UK., Walton C; Diabetes Department, Hull Royal Infirmary, Hull, UK., Greenstone MA; Respiratory Department, Castle Hill Hospital, Cottingham, UK., Ryder REJ; Diabetes Department, Sandwell & West Birmingham NHS Trust, Birmingham, UK.
Jazyk: angličtina
Zdroj: Clinical obesity [Clin Obes] 2024 Dec; Vol. 14 (6), pp. e12694. Date of Electronic Publication: 2024 Aug 11.
DOI: 10.1111/cob.12694
Abstrakt: We aimed to assess the extent to which people with type 2 diabetes or pre-diabetes, obesity (BMI 30-45 kg/m 2 ) and moderate obstructive sleep apnoea (OSA) requiring continuous positive airway pressure ventilation (CPAP) were able to discontinue CPAP following EndoBarrier-related weight loss. We assessed sleep and metabolic parameters before, during and after EndoBarrier in 12 participants with moderate OSA requiring CPAP (75% female, 8/12 [66%] type 2 diabetes, 4/12 [34%] prediabetes, mean ± SD age 52.6 ± 9.7 years, BMI 37.4 ± 3.5 kg/m 2 , median duration of OSA while on CPAP 9.0 [7.0-15.0] months). With EndoBarrier in-situ, mean ± SD Apnoea Hypopnoea Index (AHI) fell by 9.1 ± 5.0 events/h from 18.9 ± 3.8 to 9.7 ± 3.0 events/h (p < .001) with an associated reduction in symptoms of daytime sleepiness (mean Epworth Sleepiness Score) such that all the 12 participants no longer required CPAP according to National Institute for Health and Care Excellence criteria. After EndoBarrier removal, 10/12 (83%) patients attended follow-up and at 12 months after removal, AHI remained below 15 in 5/10 (50%) patients but in other five the AHI rose above 15 such that restarting CPAP was recommended as justified by their symptoms. Rather than restart CPAP, two patients lost the regained weight and their AHI dropped below 15 again. Thus, 7/10 (70%) of patients were able to remain off CPAP 12 or more months after EndoBarrier removal. These results demonstrate major benefit of EndoBarrier in moderate OSA, allowing all patients to discontinue CPAP during treatment, and with maintenance of improvement at follow-up in 70%. They confirm previously demonstrated metabolic improvements in diabetes and obesity.
(© 2024 The Author(s). Clinical Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.)
Databáze: MEDLINE
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