Examining the association between autism spectrum disorder and atopic eczema: meta-analysis of current evidence.

Autor: Elgenidy A; Faculty of Medicine, Cairo University, Cairo, Egypt., Gad EF; Pediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt., Shabaan I; Department of Psychiatry, Faculty of Medicine, Al Azhar University, Assiut, Egypt., Abdelrhem H; Faculty of Science, Cairo University, Cairo, Egypt., Wassef PG; Faculty of Medicine, Cairo University, Cairo, Egypt., Elmozugi T; Faculty of Medicine, Benghazi University, Benghazi, Libya., Abdelfattah M; Faculty of Medicine, Cairo University, Cairo, Egypt., Mousa H; Faculty of Medicine, Cairo University, Cairo, Egypt., Nasr M; Faculty of Medicine, Al-Azhar University, New Damietta, Egypt., Salah-Eldin M; Faculty of Medicine, Mansoura University, Mansoura, Egypt., Altaweel A; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Hussein A; Faculty of Medicine, Cairo University, Cairo, Egypt., Bazzazeh M; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Elganainy MA; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Ali AM; Pediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt., Ezzat M; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Elhoufey A; Department of Community Health Nursing, Alddrab University College, Jazan University, Jazan, 45142, Saudi Arabia.; Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt., Alatram AA; Department of Psychiatry, College of Medicine, Majmaah University, Al Majmaah, Saudi Arabia., Hammour A; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Saad K; Pediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt. khaled.ali@med.au.edu.eg.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2024 Aug 11. Date of Electronic Publication: 2024 Aug 11.
DOI: 10.1038/s41390-024-03456-1
Abstrakt: Objectives: This study aims to investigate the association between autism spectrum disorder (ASD) and atopic eczema (AE), shedding light on potential associations and underlying mechanisms.
Methods: A comprehensive review of literature was conducted to identify relevant studies published up to August 2023. Various electronic databases, including PubMed, Embase, Scopus, Web of Science, and Cochrane, were searched using specific keywords related to ASD and AE.
Results: The meta-analysis covered a total of 30 studies. The first analysis included 23 studies with a combined total of 147430 eczema patients in the ASD group and 8895446 eczema patients in non-ASD group. We calculated the risk ratio of eczema in ASD and non-ASD groups, which revealed a significantly higher risk of eczema in patients with ASD (RR 1.34; 95% CI 1.03, 1.76). The second analysis included seven studies with a combined total of 3570449 ASD patients in the AE group and 3253973 in the non-Eczema group. The risk ratio of ASD in the Eczema and Non-Eczema groups showed an insignificantly increased risk of ASD in patients with eczema (RR 1.67; 95% CI 0.91, 3.06).
Conclusion: This study underscores the possible link between ASD and atopic eczema, shedding light on their potential association.
Impact: Our study conducted a meta-analysis on the association between autism spectrum disorder (ASD) and atopic eczema (AE), shedding light on potential associations and underlying mechanisms. The review we conducted covered a total of 30 studies. This study underscores the possible link between ASD and atopic eczema, shedding light on their potential association.
(© 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
Databáze: MEDLINE
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