The dual role of microglia in intracerebral hemorrhage.

Autor: Sun Y; Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China., Sun W; Faculty of Chinese Medicine Sciense Guangxi University of Chinese Medicine, Nanning, Guangxi 530000, China., Liu J; Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China., Zhang B; Clinical Key Laboratory of Integrated Traditional Chinese and Western Medicine of Heilongjiang University of Chinese Medicine, Harbin 150040, China., Zheng L; Clinical Key Laboratory of Integrated Traditional Chinese and Western Medicine of Heilongjiang University of Chinese Medicine, Harbin 150040, China., Zou W; The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China. Electronic address: 18838128224@163.com.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2024 Sep 13; Vol. 473, pp. 115198. Date of Electronic Publication: 2024 Aug 10.
DOI: 10.1016/j.bbr.2024.115198
Abstrakt: Intracerebral hemorrhage has the characteristics of high morbidity, disability and mortality, which has caused a heavy burden to families and society. Microglia are resident immune cells in the central nervous system, and their activation plays a dual role in tissue damage after intracerebral hemorrhage. The damage in cerebral hemorrhage is embodied in the following aspects: releasing inflammatory factors and inflammatory mediators, triggering programmed cell death, producing glutamate induced excitotoxicity, and destroying blood-brain barrier; The protective effect is reflected in the phagocytosis and clearance of harmful substances by microglia, and the secretion of anti-inflammatory and neurotrophic factors. This article summarizes the function of microglia and its dual regulatory mechanism in intracerebral hemorrhage. In the future, drugs, acupuncture and other clinical treatments can be used to intervene in the activation state of microglia, so as to reduce the harm of microglia.
Competing Interests: Declaration of Competing Interest The authors have nothing to declare and have no conflict of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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