Visceral adiposity is associated with iron deposition and myelin loss in the brains of aged mice.

Autor: Jang G; Department of Pharmacology, College of Medicine, Ewha Womans University, Seoul, 07084, Republic of Korea., Lee EM; Department of Pharmacology, College of Medicine, Ewha Womans University, Seoul, 07084, Republic of Korea., Kim HJ; Department of Pharmacology, College of Medicine, Ewha Womans University, Seoul, 07084, Republic of Korea., Park Y; Department of Pharmacology, College of Medicine, Ewha Womans University, Seoul, 07084, Republic of Korea., Bang NH; School of Medicine, Ewha Womans University, Seoul, 07084, Republic of Korea., Lee Kang J; Inflammation-Cancer Microenvironment Research Center, College of Medicine, Ewha Womans University, 07084, Republic of Korea; Department of Physiology, College of Medicine, Ewha Womans University, Seoul, 07084, Republic of Korea. Electronic address: jihee@ewha.ac.kr., Park EM; Department of Pharmacology, College of Medicine, Ewha Womans University, Seoul, 07084, Republic of Korea. Electronic address: empark@ewha.ac.kr.
Jazyk: angličtina
Zdroj: Neurochemistry international [Neurochem Int] 2024 Oct; Vol. 179, pp. 105833. Date of Electronic Publication: 2024 Aug 13.
DOI: 10.1016/j.neuint.2024.105833
Abstrakt: Iron deposition and myelin loss are observed in the brain with aging, and iron accumulation is suggested to be involved in myelin damage. However, the exact mechanism of iron deposition with aging remains unclear. This study was aimed to determine whether expanded visceral adipose tissue contributes to iron deposition and myelin loss by inducing hepcidin in the brains of aged male mice. Compared with young adult mice, levels of hepcidin in the brain, epididymal adipose tissue, and circulation were increased in aged mice, which had expanded visceral adipose tissue with inflammation. An increase in expressions of ferritin, an indicator of intracellular iron status, was accompanied by decreased levels of proteins related to myelin sheath in the brains of aged mice. These age-related changes in the brain were improved by visceral fat removal. In addition, IL-6 level, activation of microglia/macrophages, and nuclear translocation of phosphorylated Smad1/5 (pSmad1/5) inducing hepcidin expression were reduced in the brains of aged mice after visceral fat removal, accompanied by decreases of pSmad1/5- and ferritin-positive microglia/macrophages and mature oligodendrocytes. These findings indicate that visceral adiposity contributes to hepcidin-mediated iron deposition and myelin loss with inflammation in the aged brain. Our results support the importance of preventing visceral adiposity for maintaining brain health in older individuals.
Competing Interests: Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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