Brain-Charting Autism and Attention-Deficit/Hyperactivity Disorder Reveals Distinct and Overlapping Neurobiology.

Autor: Bedford SA; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom. Electronic address: ajb349@cam.ac.uk., Lai MC; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Margaret and Wallace McCain Centre for Child, Youth & Family Mental Health and Azrieli Adult Neurodevelopmental Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan., Lombardo MV; Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy., Chakrabarti B; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Centre for Autism, School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom., Ruigrok A; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, Canada., Suckling J; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom., Anagnostou E; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada; Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Lerch JP; Program in Neurosciences and Mental Health, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Taylor M; Program in Neurosciences and Mental Health, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada., Nicolson R; Department of Psychiatry, University of Western Ontario, London, Ontario, Canada., Stelios G; McMaster University, Hamilton, Ontario, Canada., Crosbie J; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Program in Neurosciences and Mental Health, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Schachar R; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Program in Neurosciences and Mental Health, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Kelley E; Department of Psychology, Queen's University, Kingston, Ontario, Canada; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada., Jones J; Department of Psychology, Queen's University, Kingston, Ontario, Canada; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada., Arnold PD; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Departments of Psychiatry and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Courchesne E; Department of Neurosciences, University of California San Diego, La Jolla, California., Pierce K; Department of Neurosciences, University of California San Diego, La Jolla, California., Eyler LT; Department of Psychiatry, University of California San Diego, La Jolla, California., Campbell K; Department of Neurosciences, University of California San Diego, La Jolla, California., Barnes CC; Department of Neurosciences, University of California San Diego, La Jolla, California., Seidlitz J; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pennsylvania., Alexander-Bloch AF; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pennsylvania., Bullmore ET; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom., Baron-Cohen S; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Cambridge Lifetime Autism Spectrum Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom., Bethlehem RAI; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Department of Psychology, University of Cambridge, Cambridge, United Kingdom.
Jazyk: angličtina
Zdroj: Biological psychiatry [Biol Psychiatry] 2024 Aug 14. Date of Electronic Publication: 2024 Aug 14.
DOI: 10.1016/j.biopsych.2024.07.024
Abstrakt: Background: Autism and attention-deficit/hyperactivity disorder (ADHD) are heterogeneous neurodevelopmental conditions with complex underlying neurobiology that is still poorly understood. Despite overlapping presentation and sex-biased prevalence, autism and ADHD are rarely studied together and sex differences are often overlooked. Population modeling, often referred to as normative modeling, provides a unified framework for studying age-specific and sex-specific divergences in brain development.
Methods: Here, we used population modeling and a large, multisite neuroimaging dataset (N = 4255 after quality control) to characterize cortical anatomy associated with autism and ADHD, benchmarked against models of average brain development based on a sample of more than 75,000 individuals. We also examined sex and age differences and relationship with autistic traits and explored the co-occurrence of autism and ADHD.
Results: We observed robust neuroanatomical signatures of both autism and ADHD. Overall, autistic individuals showed greater cortical thickness and volume that was localized to the superior temporal cortex, whereas individuals with ADHD showed more global increases in cortical thickness but lower cortical volume and surface area across much of the cortex. The co-occurring autism+ADHD group showed a unique pattern of widespread increases in cortical thickness and certain decreases in surface area. We also found that sex modulated the neuroanatomy of autism but not ADHD, and there was an age-by-diagnosis interaction for ADHD only.
Conclusions: These results indicate distinct cortical differences in autism and ADHD that are differentially affected by age and sex as well as potentially unique patterns related to their co-occurrence.
(Copyright © 2024 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: