Rituximab-induced cystoid macular edema in a patient with systemic lupus erythematosus: A case report and literature review.

Autor: Lobo-Antuña V; Internal Medicine Department, Consorcio Hospital General Universitario de Valencia, Valencia, Spain. Electronic address: viclobo@ucm.es., Cherti-Afailal A; Internal Medicine Department, Hospital Universitario de Ceuta, Ceuta, Spain., García-Morales M; Autoimmune Diseases Unit, Internal Medicine Department, Hospital Universitario Clínico San Cecilio, Granada, Spain., Ríos-Fernández R; Autoimmune Diseases Unit, Internal Medicine Department, Hospital Universitario Clínico San Cecilio, Granada, Spain., de la Hera-Fernández FJ; Autoimmune Diseases Unit, Internal Medicine Department, Hospital Universitario Clínico San Cecilio, Granada, Spain., García-Serrano JL; Ophthalmology Department, Hospital Universitario Clínico San Cecilio, Granada, Spain., Callejas-Rubio JL; Autoimmune Diseases Unit, Internal Medicine Department, Hospital Universitario Clínico San Cecilio, Granada, Spain.
Jazyk: angličtina
Zdroj: Autoimmunity reviews [Autoimmun Rev] 2024 Jul-Aug; Vol. 23 (7-8), pp. 103588. Date of Electronic Publication: 2024 Aug 10.
DOI: 10.1016/j.autrev.2024.103588
Abstrakt: Cystoid macular edema (CME) is considered a rare adverse effect of rituximab use, with only a limited number of cases published in the literature. Although its etiopathogenesis is still unknown, its mechanism seems to be related to a transient elevation of cytokines after rituximab infusion resulting in an increased permeability of retinal vessels. We report the first case of rituximab-induced CME in a patient with systemic lupus erythematosus (SLE), where rituximab was used to treat hematological complications. A month after the 2nd infusion, the patient developed blurred vision and decreased visual acuity in the right eye. An optic coherence tomography (OCT) was performed, being diagnosed with CME. Rituximab was then discontinued, exhibiting a complete resolution of the condition within 4 weeks. The aim of our work is to report the first case in a patient with SLE and also carry out a brief review of the subject comparing it to all previously published cases.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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