Balancing Plk1 activity levels: The secret of synchrony between the cell and the centrosome cycle.

Autor: Dwivedi D; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Translational Research Centre in Onco-haematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Meraldi P; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Translational Research Centre in Onco-haematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Jazyk: angličtina
Zdroj: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 Oct; Vol. 46 (10), pp. e2400048. Date of Electronic Publication: 2024 Aug 11.
DOI: 10.1002/bies.202400048
Abstrakt: The accuracy of cell division requires precise regulation of the cellular machinery governing DNA/genome duplication, ensuring its equal distribution among the daughter cells. The control of the centrosome cycle is crucial for the formation of a bipolar spindle, ensuring error-free segregation of the genome. The cell and centrosome cycles operate in close synchrony along similar principles. Both require a single duplication round in every cell cycle, and both are controlled by the activity of key protein kinases. Nevertheless, our comprehension of the precise cellular mechanisms and critical regulators synchronizing these two cycles remains poorly defined. Here, we present our hypothesis that the spatiotemporal regulation of a dynamic equilibrium of mitotic kinases activities forms a molecular clock that governs the synchronous progression of both the cell and the centrosome cycles.
(© 2024 The Author(s). BioEssays published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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