Vitamins Can Increase Antibiotic Effects Against Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii in an In Vitro Infection Model.
| Autor: | Çelebi Ö; Department of Medical Microbiology, Ataturk University Faculty of Medicine, Erzurum, Turkey., Çelebi D; Department of Microbiology, Ataturk University Faculty of Veterinary Medicine, Erzurum, Turkey., Başer S; Department of Medical Microbiology, Ataturk University Faculty of Medicine, Erzurum, Turkey., Yılmaz A; Department of Medical Pharmacology, Amasya University Faculty of Medicine, Amasya, Turkey., Yıldırım S; Department of Pathology, Ataturk University Faculty of Veterinary Medicine, Erzurum, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | The Eurasian journal of medicine [Eurasian J Med] 2024 Jun; Vol. 56 (2), pp. 91-97. |
| DOI: | 10.5152/eurasianjmed.2024.23145 |
| Abstrakt: | Methods: The study delves into the antimicrobial properties of vitamins P, K, and E against A. baumannii and P. aeruginosa, employing the minimum inhibitory concentration method and scrutinizing biofilm formation within the A549 cell culture. Results: The combined application of vitamins and antibiotics exhibited a statistically significant effect on both the minimal inhibitory concentration values and biofilm formation (P < .05). Within the realm of fat-soluble vitamins, vitamins K and E, when integrated with antibiotics, revealed varying degrees of influence, with vitamin K displaying the most substantial fractional inhibitory concentration value. Vitamin E, on the other hand, demonstrated a comparatively weaker fractional inhibitory concentration than the other constituents. Nevertheless, it exhibited robust optical density and a pronounced capacity to inhibit biofilm formation. Moreover, among the vitamin groups, it is evident that vitamin E surpasses the efficacy of others (antibacterials affecting K < P |
| Databáze: | MEDLINE |
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