Genetic Features of Tongue Cancer Recurrence in Young Adults.

Autor: Kolegova ES; Cancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. elenakolegova@oncology.tomsk.ru., Schegoleva AA; Cancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia., Vorobev RS; Cancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia., Fedorova IK; Cancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia., Kulbakin DE; Cancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia., Polyakov AP; P. Hertsen Moscow Oncology Research Institute - Branch of National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Moscow, Russia., Mordovsky AV; P. Hertsen Moscow Oncology Research Institute - Branch of National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Moscow, Russia., Yakovleva LP; Moscow Clinical Scientific Center named after Loginov, Moscow Healthcare Department, Moscow, Russia., Vyalov AS; Moscow Clinical Scientific Center named after Loginov, Moscow Healthcare Department, Moscow, Russia., Tsiklauri VT; N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia., Kropotov MA; N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia., Suchkova NG; Main Military Clinical Hospital named after academician N. N. Burdenko, Ministry of Defense of the Russian Federation, Moscow, Russia., Sukortseva NS; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia., Reshetov IV; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia., Choinzonov EL; Cancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia., Denisov EV; Cancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Jul; Vol. 177 (3), pp. 359-362. Date of Electronic Publication: 2024 Aug 11.
DOI: 10.1007/s10517-024-06189-7
Abstrakt: To identify genetic alterations associated with tongue cancer recurrence in young adults, whole exome sequencing of the primary tumor, recurrence, and whole blood samples from young patients with tongue cancer was performed. A frameshift mutation in the TP53 gene was detected in the primary tumor and recurrence tumor tissue. A mutation in the EPHB6 gene was detected in the recurrence and was absent in the primary tumor. In addition, the primary tumor and recurrence tongue cancer tissue harbored amplification of the 20p13 region containing C20orf96, DEFB125, DEFB126, DEFB127, DEFB128, DEFB129, DEFB132, and ZCCHC3 genes. Thus, genetic alterations have been identified that are associated with tongue cancer recurrence in young adults.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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