Comparisons of the oncological results of transoral laser surgery and radiotherapy for early stage laryngeal squamous cell cancer: single-center long-term results.

Autor:	Doluoglu S; From the Department of Otorhinolaryngology, Ankara Etlik Integrated Health Campus, Ankara, Turkey., Bayir O; From the Department of Otorhinolaryngology, Ankara Etlik Integrated Health Campus, Ankara, Turkey., Ocal B; From the Department of Otorhinolaryngology, Ankara Etlik Integrated Health Campus, Ankara, Turkey., Tatar EC; From the Department of Otorhinolaryngology, Ankara Etlik Integrated Health Campus, Ankara, Turkey., Korkmaz MH; From the Department of Otorhinolaryngology, Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey., Saylam G; From the Department of Otorhinolaryngology, Ankara Etlik Integrated Health Campus, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	Annals of Saudi medicine [Ann Saudi Med] 2024 Jul-Aug; Vol. 44 (4), pp. 213-219. Date of Electronic Publication: 2024 Aug 01.
DOI:	10.5144/0256-4947.2024.213
Abstrakt:	Background: In the treatment of early stage laryngeal cancers, surgery (transoral laryngeal surgery (TOLS), open partial laryngeal surgery (OPLS) and radiotherapy (RT) are used. Objectives: Compare the oncological results of patients with early stage laryngeal squamous cell carcinoma (LSCC) treated with TOLS or RT. Design: Retrospective. Settings: Tertiary training and research hospital. Patients and Methods: The participants were divided into patients who underwent TOLS and RT treatment. The groups were compared with each other in terms of local recurrence, regional recurrence, distant metastasis, 3 and 5-year overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS) and laryngectomy-free survival rates (LFS). Main Outcome Measures: The effects of TOLS and RT treatment on local control, regional control, OS, DFS, DDS and LFS in early stage laryngeal cancers. Sample Size: 261. Results: The mean follow-up time was 48 (26) months. There were 186 patients who underwent TOLS and 75 patients who underwent RT treatment. Gender, cigarette/alcohol consumption, tumor localization, anterior commissure involvement, tumor grades, recurrence rates and recurrence localizations of the groups were similar. The 5-year overall, disease specific, disease free and laryngectomy-free survival rates were 85.9%, 88%, 79.4%, 96.3% in the TOLS group and 74.3%, 76.7%, 72.3%, 85.2% in the RT group ( P =.034, .065, .269, .060, respectively). Conclusions: TOLS had equal and good oncological outcomes on OS and DFS compared to RT. Anterior commissure involvement was statistically significant independent prognostic risk factor for DFS in both groups. The 5-year OS rate was greater in the TOLS groups ( P =.034). Limitations: Retrospective, but to the best our knowledge, this is the first study in Turkey with a high patient volume and a long follow-up time.
Databáze:	MEDLINE
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