Polysaccharides extracted from tucum-do-cerrado fruits (Bactris setosa Mart) have antineoplastic effects in mice while preserving hepatic gluconeogenesis.

Autor: de Oliveira KM; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Abboud KY; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Radulski DR; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Faria BC; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Galindo CM; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Pereira GS; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Stipp MC; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Corso CR; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., de Assis CB; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., de Lima Martins JN; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., do Amaral LA; Postgraduate Program in Health and Development in the Midwest Region, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., Comar JF; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Cordeiro LMC; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Acco A; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil. Electronic address: aleacco@ufpr.br.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 278 (Pt 3), pp. 134590. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1016/j.ijbiomac.2024.134590
Abstrakt: This study investigated the antitumoral, anti-inflammatory and oxidative effects of polysaccharides from tucum (Bactris setosa, TUC) using the Ehrlich carcinoma as a tumor model. Additionally, the glycogen content, cytochrome P levels, and gluconeogenesis from lactate were assessed in the liver of healthy animals. Tumor-bearing female mice were orally treated with 50 and 100 mg.kg -1 of TUC or vehicle, once a day, or with 1.5 mg.kg -1 methotrexate via i.p., every 3 days, along 21 days. Both doses of TUC reduced the tumor weight and volume. In the tumor tissue, it decreased GSH and IL-1β levels, and increased LPO, NAG, NO and TNF-α levels. The tumor histology showed necrosis and leukocytes infiltration. The metabolic effects of TUC were investigated by measurement of total cytochrome P (CYP) and glycogen in tumor-bearing mice, and by ex vivo liver perfusion on non-bearing tumor male mice, using lactate as gluconeogenic precursor. Metabolically, the hepatic glucose and pyruvate productions, oxygen uptake, and the total CYP concentration were not modified by TUC. Thus, tucum-do-cerrado polysaccharides have antitumor effects through the modulation of oxidative stress and inflammation, without impairing glucose production from lactate in the liver, the main organ responsible for the metabolism of organic and xenobiotic compounds.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Alexandra Acco, Lucimara Mach Cordeiro reports financial support was provided by National Council for Scientific and Technological Development. Kaue Marcel de Oliveira, Kahlile Youseff Abboud, Debora Rasec Radulski, Bruna Christ Faria, Claudia Martins Galindo, Gabriela Saidel Pereira, Maria Carolina Stipp reports financial support was provided by Coordination of Higher Education Personnel Improvement. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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