Visual toxicity in zebrafish larvae following exposure to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), triphenyl phosphate (TPhP), and isopropyl phenyl diphenyl phosphate (IPPP).

Autor: Luo C; Department of Preventive Medicine, Shantou University Medical College, Shantou 515041, Guangdong, China., Zhang Q; Department of Preventive Medicine, Shantou University Medical College, Shantou 515041, Guangdong, China., Zheng S; Department of Burns and Plastic Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong, China., Wang D; Department of Preventive Medicine, Shantou University Medical College, Shantou 515041, Guangdong, China., Huang W; Department of Forensic Medicine, Shantou University Medical College, Shantou 515041, Guangdong, China., Huang Y; Mental Health Center of Shantou University, Shantou, Guangdong, China., Shi X; Department of Preventive Medicine, Shantou University Medical College, Shantou 515041, Guangdong, China., Xie H; Department of Preventive Medicine, Shantou University Medical College, Shantou 515041, Guangdong, China., Wu K; Department of Preventive Medicine, Shantou University Medical College, Shantou 515041, Guangdong, China. Electronic address: kswu@stu.edu.cn.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Nov 10; Vol. 950, pp. 175131. Date of Electronic Publication: 2024 Aug 09.
DOI: 10.1016/j.scitotenv.2024.175131
Abstrakt: TPhP and IPPP, alternatives to PBDEs as flame retardants, have been studied for their developmental toxicity, but their visual toxicities are less understood. In this study, zebrafish larvae were exploited to evaluate the potential ocular impairments following exposure to BDE-47, TPhP, and IPPP. The results revealed a range of ocular abnormalities, including malformation, vascular issues within the eyes, and histopathological changes in the retina. Notably, the visually mediated behavioral changes were primarily observed in IPPP and TPhP, indicating that they caused more severe eye malformations and vision impairment than BDE-47. Molecular docking and MD simulations showed stronger binding affinity of TPhP and IPPP to RAR and RBP receptors. Elevated ROS and T3 levels induced by these compounds led to apoptosis in larvae eyes, and increased GABA levels induced by TPhP and IPPP hindered retinal repair. In summary, our results indicate TPhP and IPPP exhibit severer visual toxicity than BDE-47, affecting eye development and visually guided behaviors. The underlying mechanism involves disruptions in RA signaling, retinal neurotransmitters imbalance, thyroid hormones up-regulation, and apoptosis in larvae eyes. This work highlights novel insights into the need for cautious use of these flame retardants due to their potential biological hazards, thereby offering valuable guidance for their safer applications.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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