Cardiac alterations induced by Heloderma horridum horridum venom in rats: An experimental study with ECG analysis using a linear regression algorithm.

Autor: Vazquez-Gonzalez KI; Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Colonia las Viboras, Colima, 28040, Mexico., Ochoa-Brust A; Facultad de Ingeniería Mecánica Eléctrica, Universidad de Colima, Kilometro 9 Carretera Colima-Coquimatlan, Coquimatlan, Colima, 28400, Mexico., Rodriguez-Hernandez A; Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Colonia las Viboras, Colima, 28040, Mexico., Ventura-Cisneros H; Clinica ISSTE Hospital Dr. Miguel Trejo Ochoa. Calle Ignacio Sandoval 867, Lomas de Circunvalación, 28010, Colima, Colima, Mexico., Lino-Lopez GJ; Centro Nacional de Referencia de Control Biológico, Dirección General de Sanidad Vegetal SENASICA SADER, Colima, 28110, Mexico., Barbosa-Valdovinos R; Hospiltal Puerta de Hierro, Calle Ignacio Sandoval 1699, Girasoles, 28018, Colima, Mexico., Rodriguez-Vazquez A; Unidad de Manejo para el Aprovechamiento de la Vida Silvestre en el Parque del 'Palapo' Domicilio Conocido P-75 Agua Zarca, Coquimatlan, 28400, Mexico., Vazquez-Vuelvas OF; Facultad de Ciencias Químicas, Universidad de Colima, Kilometro 9 Carretera Colima-Coquimatlan, Coquimatlan, Colima, 28400, Mexico., Felix RA; Facultad de Ingeniería Mecánica Eléctrica, Universidad de Colima, Kilometro 9 Carretera Colima-Coquimatlan, Coquimatlan, Colima, 28400, Mexico., Jiménez-Vargas JM; Facultad de Ciencias Químicas, Universidad de Colima, Kilometro 9 Carretera Colima-Coquimatlan, Coquimatlan, Colima, 28400, Mexico., Melnikov V; Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Colonia las Viboras, Colima, 28040, Mexico. Electronic address: melnik@ucol.mx., Valdez-Velazquez LL; Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Colonia las Viboras, Colima, 28040, Mexico; Facultad de Ciencias Químicas, Universidad de Colima, Kilometro 9 Carretera Colima-Coquimatlan, Coquimatlan, Colima, 28400, Mexico. Electronic address: lauravaldez@ucol.mx.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Oct; Vol. 249, pp. 108062. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1016/j.toxicon.2024.108062
Abstrakt: Envenomation by reptile venom, particularly from lizards, poses significant health risks and can lead to physiological and cardiovascular changes. The venom of Heloderma horridum horridum, endemic to Colima, Mexico, was tested on Wistar rats. Electrocardiographic (ECG) data were collected pre-treatment and at 5-min intervals for 1 h post-envenomation. A specially designed computational linear regression algorithm (LRA) was used for the segmentation analysis of the ECG data to improve the detection of fiducial points (P, Q, R, S, and T) in ECG waves. Additionally, heart tissue was analyzed for macroscopic and microscopic changes. The results revealed significant electrocardiographic alterations, including pacemaker migration, junctional extrasystoles, and intraventricular conduction aberrations. By applying a linear regression algorithm, the study compensated for noise and anomalies in the isoelectric line in an ECG signal, improving the detection of P and T waves and the QRS complex with an efficiency of 97.5%. Cardiac enzyme evaluation indicated no statistically significant differences between the control and experimental groups. Macroscopic and microscopic examination revealed no apparent signs of damage or inflammatory responses in heart tissues. This study enhances our understanding of the cardiovascular impact of Heloderma venom, suggesting a greater influence on changes in conduction and arrhythmias than on direct cardiac damage to the myocardium.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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