Relationship between Respiratory Microbiome and Systemic Inflammatory Markers in COPD: A Pilot Study.

Autor: Casadevall C; Hospital del Mar Research Institute (IMIM), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain.; Centro de Investigación Biomédica en Red, Área de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain., Quero S; Centro de Investigación Biomédica en Red, Área de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Airway Inflammation Research Group, Parc Taulí Research and Innovation Institute-I3PT-Parc Taulí Foundation, 08208 Sabadell, Spain., Millares L; Airway Inflammation Research Group, Parc Taulí Research and Innovation Institute-I3PT-Parc Taulí Foundation, 08208 Sabadell, Spain.; Catalan Institute of Oncology-ICO, Hospitalet de Llobregat, 08908 Barcelona, Spain., Faner R; Centro de Investigación Biomédica en Red, Área de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Servei de Pneumologia (Institut Clínic de Respiratori) and Dispositiu Transversal d'Hospitalització a Domicili (Direcció Mèdica i d'Infermeria), Hospital Clínic-Fundació Clínic per la Recerca Biomèdica, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Cosío BG; Centro de Investigación Biomédica en Red, Área de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Servei de Pneumologia, Hospital Son Espases-Institut d'Investigació Sanitària de Palma (IdISBa), 07120 Palma de Mallorca, Spain., Peces-Barba G; Centro de Investigación Biomédica en Red, Área de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Servicio de Neumología, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, 28049 Madrid, Spain., Castro-Acosta A; Servicio de Neumología, Hospital 12 de Octubre, 28041 Madrid, Spain., Montón C; Airway Inflammation Research Group, Parc Taulí Research and Innovation Institute-I3PT-Parc Taulí Foundation, 08208 Sabadell, Spain.; Servei de Pneumologia, Hospital Universitari Parc Taulí, 08208 Sabadell, Spain., Palou A; Servei de Pneumologia, Hospital Son Espases-Institut d'Investigació Sanitària de Palma (IdISBa), 07120 Palma de Mallorca, Spain., Pascual-Guardia S; Hospital del Mar Research Institute (IMIM), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain.; Servei de Pneumologia, Hospital del Mar, 08003 Barcelona, Spain., Agustí A; Centro de Investigación Biomédica en Red, Área de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Servei de Pneumologia (Institut Clínic de Respiratori) and Dispositiu Transversal d'Hospitalització a Domicili (Direcció Mèdica i d'Infermeria), Hospital Clínic-Fundació Clínic per la Recerca Biomèdica, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Gea J; Hospital del Mar Research Institute (IMIM), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain.; Centro de Investigación Biomédica en Red, Área de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.; Servei de Pneumologia, Hospital del Mar, 08003 Barcelona, Spain., Monsó E; Airway Inflammation Research Group, Parc Taulí Research and Innovation Institute-I3PT-Parc Taulí Foundation, 08208 Sabadell, Spain., On Behalf Of The Biomepoc Group
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 02; Vol. 25 (15). Date of Electronic Publication: 2024 Aug 02.
DOI: 10.3390/ijms25158467
Abstrakt: The respiratory microbiome may influence the development and progression of COPD by modulating local immune and inflammatory events. We aimed to investigate whether relative changes in respiratory bacterial abundance are also associated with systemic inflammation, and explore their relationship with the main clinical COPD phenotypes. Multiplex analysis of inflammatory markers and transcript eosinophil-related markers were analyzed on peripheral blood in a cohort of stable COPD patients (n = 72). Respiratory microbiome composition was analyzed by 16S rRNA microbial sequencing on spontaneous sputum. Spearman correlations were applied to test the relationship between the microbiome composition and systemic inflammation. The concentration of the plasma IL-8 showed an inverted correlation with the relative abundance of 17 bacterial genera in the whole COPD cohort. COPD patients categorized as eosinophilic showed positive relationships with blood eosinophil markers and inversely correlated with the degree of airway obstruction and the number of exacerbations during the previous year. COPD patients categorized as frequent exacerbators were enriched with the bacterial genera Pseudomonas which, in turn, was positively associated with the severity of airflow limitation and the prior year's exacerbation history. The associative relationships of the sputum microbiome with the severity of the disease emphasize the relevance of the interaction between the respiratory microbiota and systemic inflammation.
Competing Interests: The authors declare no conflicts of interest.
Databáze: MEDLINE
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