Age-Related Retinal Layer Thickness Changes Measured by OCT in APP NL-F/NL-F Mice: Implications for Alzheimer's Disease.

Autor: Sánchez-Puebla L; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain.; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.; Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain., de Hoz R; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain.; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.; Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, Spain., Salobrar-García E; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain.; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.; Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, Spain., Arias-Vázquez A; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain., González-Jiménez M; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain., Ramírez AI; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain.; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.; Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, Spain., Fernández-Albarral JA; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain.; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.; Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, Spain., Matamoros JA; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, Spain., Elvira-Hurtado L; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain., Saido TC; Brain Science Institute, RIKEN, Laboratory for Proteolytic Neuroscience, Wako 351-0198, Japan., Saito T; Institute of Brain Science, Faculty of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan., Nieto Vaquero C; Neurovascular Pathophysiology, Cardiovascular Risk Factor and Brain Function Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.; Hospital 12 de Octubre Research Institute (i + 12), 28041 Madrid, Spain.; University Institute for Research in Neurochemistry, Complutense University of Madrid (UCM), 28040 Madrid, Spain., Cuartero MI; Hospital 12 de Octubre Research Institute (i + 12), 28041 Madrid, Spain.; University Institute for Research in Neurochemistry, Complutense University of Madrid (UCM), 28040 Madrid, Spain.; Department of Pharmacology and Toxicology, Faculty of Medicine, Complutense University of Madrid (UCM), 28040 Madrid, Spain., Moro MA; Neurovascular Pathophysiology, Cardiovascular Risk Factor and Brain Function Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain., Salazar JJ; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain.; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.; Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, Spain., López-Cuenca I; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain.; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.; Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, Spain., Ramírez JM; Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain.; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.; Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 27; Vol. 25 (15). Date of Electronic Publication: 2024 Jul 27.
DOI: 10.3390/ijms25158221
Abstrakt: In Alzheimer's disease (AD), transgenic mouse models have established links between abnormalities in the retina and those in the brain. APP NL-F/NL-F is a murine, humanized AD model that replicates several pathological features observed in patients with AD. Research has focused on obtaining quantitative parameters from optical coherence tomography (OCT) in AD. The aim of this study was to analyze, in a transversal case-control study using manual retinal segmentation via SD-OCT, the changes occurring in the retinal layers of the APP NL/F-NF/L AD model in comparison to C57BL/6J mice (WT) at 6, 9, 12, 15, 17, and 20 months of age. The analysis focused on retinal thickness in RNFL-GCL, IPL, INL, OPL, and ONL based on the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors. Both APP NL-F/NL-F -model and WT animals exhibited thickness changes at the time points studied. While WT showed significant changes in INL, OPL, and ONL, the AD model showed changes in all retinal layers analyzed. The APP NL-F/NL-F displayed significant thickness variations in the analyzed layers except for the IPL compared to related WT. These thickness changes closely resembled those found in humans during preclinical stages, as well as during mild and moderate AD stages, making this AD model behave more similarly to the disease in humans.
Databáze: MEDLINE
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