Persimmon Fiber-Rich Ingredients Promote Anti-Inflammatory Responses and the Growth of Beneficial Anti-Inflammatory Firmicutes Species from the Human Colon.

Autor:	López-Bermudo L; Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), Pablo de Olavide University, University of Seville, CSIC, 41092 Seville, Spain.; Biomedical Research Network on Diabetes and Related Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain., Moreno-Chamba B; Institute of Research, Development and Innovation in Sanitary Biotechnology of Elche, Miguel Hernández University, 03202 Elche, Spain.; Institute of Food Engineering for Development, Universitat Politècnica de València, 46022 Valencia, Spain., Salazar-Bermeo J; Institute of Research, Development and Innovation in Sanitary Biotechnology of Elche, Miguel Hernández University, 03202 Elche, Spain.; Institute of Food Engineering for Development, Universitat Politècnica de València, 46022 Valencia, Spain., Hayward NJ; Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK., Morris A; Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK., Duncan GJ; Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK., Russell WR; Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK., Cárdenas A; Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), Pablo de Olavide University, University of Seville, CSIC, 41092 Seville, Spain.; Biomedical Research Network on Diabetes and Related Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain., Ortega Á; Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), Pablo de Olavide University, University of Seville, CSIC, 41092 Seville, Spain.; Biomedical Research Network on Diabetes and Related Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain., Escudero-López B; Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), Pablo de Olavide University, University of Seville, CSIC, 41092 Seville, Spain.; Biomedical Research Network on Diabetes and Related Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain., Berná G; Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), Pablo de Olavide University, University of Seville, CSIC, 41092 Seville, Spain.; Biomedical Research Network on Diabetes and Related Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain., Martí Bruña N; Institute of Research, Development and Innovation in Sanitary Biotechnology of Elche, Miguel Hernández University, 03202 Elche, Spain., Duncan SH; Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK., Neacsu M; Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK., Martin F; Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), Pablo de Olavide University, University of Seville, CSIC, 41092 Seville, Spain.; Biomedical Research Network on Diabetes and Related Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2024 Aug 01; Vol. 16 (15). Date of Electronic Publication: 2024 Aug 01.
DOI:	10.3390/nu16152518
Abstrakt:	Persimmon fruit processing-derived waste and by-products, such as peels and pomace, are important sources of dietary fiber and phytochemicals. Revalorizing these by-products could help promote circular nutrition and agricultural sustainability while tackling dietary deficiencies and chronic diseases. In this study, fiber-rich fractions were prepared from the by-products of Sharoni and Brilliant Red persimmon varieties. These fractions were quantified for their phenolic composition and assessed for their ability to promote the growth of beneficial human colonic Firmicutes species and for their in vitro anti-inflammatory potential. Gallic and protocatechuic acids, delphinidin, and cyanidin were the main phenolics identified. Faecalibacterium prausnitzii strains showed significantly higher growth rates in the presence of the Brilliant Red fraction, generating more than double butyrate as a proportion of the total short-chain fatty acids (39.5% vs. 17.8%) when compared to glucose. The fiber-rich fractions significantly decreased the inflammatory effect of interleukin-1β in Caco-2 cells, and the fermented fractions (both from Sharoni and Brilliant Red) significantly decreased the inflammatory effect of interleukin-6 and tumor necrosis factor-α in the RAW 264.7 cells. Therefore, fiber-rich fractions from persimmon by-products could be part of nutritional therapies as they reduce systemic inflammation, promote the growth of beneficial human gut bacteria, and increase the production of beneficial microbial metabolites such as butyrate.
Databáze:	MEDLINE
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