Brain Perception of Different Oils on Appetite Regulation: An Anorectic Gene Expression Pattern in the Hypothalamus Dependent on the Vagus Nerve.

Autor: Lopes GCA; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil., Miranda BCR; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil., Lima JOPF; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil., Martins JA; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil., de Sousa AA; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil., Nobre TA; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil., Severo JS; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil., da Silva TEO; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 17012-900, SP, Brazil., Afonso MDS; Department of Inflammation and Fibrosis, Gilead Sciences, Foster City, CA 94404, USA., Lima JDCC; Cancer Metabolism Research Group, Department of Surgery and LIM26-HCFMUSP, Faculty of Medicine, University of São Paulo, São Paulo 17012-900, SP, Brazil., de Matos Neto EM; Department of Physical Education, Federal University of Piauí, Teresina 64049-550, PI, Brazil., Torres LRO; Federal Institute of Education, Science and Technology of Maranhão, Caxias 65030-005, MA, Brazil., Cintra DE; Laboratory of Nutritional Genomics, University of Campinas, Campinas 13083-855, SP, Brazil.; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences University of Campinas, São Paulo 13083-970, SP, Brazil.; Hospital Israelita Albert Einstein (HIAE), São Paulo 05652-900, SP, Brazil., Lottenberg AM; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences University of Campinas, São Paulo 13083-970, SP, Brazil.; Hospital Israelita Albert Einstein (HIAE), São Paulo 05652-900, SP, Brazil.; Laboratório de Lípides (LIM10), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, University of São Paulo, São Paulo 17012-900, SP, Brazil., Seelaender M; Cancer Metabolism Research Group, Department of Surgery and LIM26-HCFMUSP, Faculty of Medicine, University of São Paulo, São Paulo 17012-900, SP, Brazil., Silva MTBD; Institute of Biomedical Sciences Abel Salazar, Center for Drug Discovery and Innovative Medicines, Laboratory of Physiology, Department of Immuno-Physiology and Pharmacology, University of Porto, 4099-002 Porto, Portugal., Torres-Leal FL; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Laboratory of Metabolic Diseases Glauto Tuquarre, Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil.
Jazyk: angličtina
Zdroj: Nutrients [Nutrients] 2024 Jul 24; Vol. 16 (15). Date of Electronic Publication: 2024 Jul 24.
DOI: 10.3390/nu16152397
Abstrakt: (1) Background: We examined the effect of the acute administration of olive oil (EVOO), linseed oil (GLO), soybean oil (SO), and palm oil (PO) on gastric motility and appetite in rats. (2) Methods: We assessed food intake, gastric retention (GR), and gene expression in all groups. (3) Results: Both EVOO and GLO were found to enhance the rate of stomach retention, leading to a decrease in hunger. On the other hand, the reduction in food intake caused by SO was accompanied by delayed effects on stomach retention. PO caused an alteration in the mRNA expression of NPY, POMC, and CART. Although PO increased stomach retention after 180 min, it did not affect food intake. It was subsequently verified that the absence of an autonomic reaction did not nullify the influence of EVOO in reducing food consumption. Moreover, in the absence of parasympathetic responses, animals that received PO exhibited a significant decrease in food consumption, probably mediated by lower NPY expression. (4) Conclusions: This study discovered that different oils induce various effects on parameters related to food consumption. Specifically, EVOO reduces food consumption primarily through its impact on the gastrointestinal tract, making it a recommended adjunct for weight loss. Conversely, the intake of PO limits food consumption in the absence of an autonomic reaction, but it is not advised due to its contribution to the development of cardiometabolic disorders.
Databáze: MEDLINE
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