| Autor: |
Ammendola M; Science of Health Department, Digestive Surgery Unit, University 'Magna Graecia' Medical School, University Hospital 'R. Dulbecco', 88100 Catanzaro, Italy., Vescio F; Science of Health Department, Digestive Surgery Unit, University 'Magna Graecia' Medical School, University Hospital 'R. Dulbecco', 88100 Catanzaro, Italy., Rotondo C; Science of Health Department, Digestive Surgery Unit, University 'Magna Graecia' Medical School, University Hospital 'R. Dulbecco', 88100 Catanzaro, Italy., Arturi F; Department of Medical and Surgical Sciences, University 'Magna Graecia' Medical School, Internal Medicine Unit, Outpatient Unit for the Treatment of Obesity, University Hospital 'R. Dulbecco', 88100 Catanzaro, Italy., Luposella M; Cardiovascular Disease Unit, General Hospital, 88100 Catanzaro, Italy., Zuccalà V; Pathology Unit, 'R. Dulbecco' University Hospital, 88100 Catanzaro, Italy., Battaglia C; Department of Experimental and Clinical Medicine, 'Magna Graecia' University Medical School, Radiology Unit, 'R. Dulbecco' University Hospital, 88100 Catanzaro, Italy., Laganà D; Department of Experimental and Clinical Medicine, 'Magna Graecia' University Medical School, Radiology Unit, 'R. Dulbecco' University Hospital, 88100 Catanzaro, Italy., Ranieri G; Oncology Unit, IRCCS National Cancer Istitute 'Giovanni Paolo II', 70100 Bari, Italy., Navarra G; Department of Human Pathology of Adult and Evolutive Age, Surgical Oncology Division, 'G. Martino' Hospital, University of Messina, 98121 Messina, Italy., Curcio S; Science of Health Department, Digestive Surgery Unit, University 'Magna Graecia' Medical School, University Hospital 'R. Dulbecco', 88100 Catanzaro, Italy., Danese V; Department of Chemistry and Technologies Pharmaceuticals, University of Bari 'Aldo Moro', 70100 Bari, Italy., Franzoso L; Department of Anesthesia and Intensive Care, 'SS. Annunziata Hospital', 74121 Taranto, Italy., De Luca GM; Academic Unit of General Surgery 'V. Bonomo', Department of Precision and Regenerative Medicine and Ionian Area, University of Bari 'A. Moro', 70100 Bari, Italy., Prete FP; Academic Unit of General Surgery 'V. Bonomo', Department of Precision and Regenerative Medicine and Ionian Area, University of Bari 'A. Moro', 70100 Bari, Italy., Testini M; Academic Unit of General Surgery 'V. Bonomo', Department of Precision and Regenerative Medicine and Ionian Area, University of Bari 'A. Moro', 70100 Bari, Italy., Currò G; Science of Health Department, University 'Magna Graecia' Medical School, 'R.Dulbecco' University Hospital, General Surgery Unit, 88100 Catanzaro, Italy. |
| Abstrakt: |
Background. Adipose tissue macrophages (ATMs) and mast cells (MCs) play a role in immune responses. More recently, their involvement in tumor angiogenesis and chronic inflammatory conditions in patients with obesity has been discovered. Furthermore, a higher BMI (Body Mass Index) value corresponds to a higher inflammatory state. In particular, gastric tissue in obesity (GTO) is characterized by Macrophages, Mast Cells Positive to Triptase (MCPT), and neo-formed microvessels (MVD). Materials and Methods. We collected gastric tissue samples from December 2021 to December 2022. The patients selected had a BMI > 35 kg/m 2 with different comorbidities. Regarding the surgery, surgeons executed a Laparoscopic Sleeve Gastrectomy (LapSG). Gastric tissue was analyzed by immunohistochemistry and morphometrical assay, comparing "obese-related" gastric tissue to normal gastric tissue. Furthermore, tissue parameters were correlated with important clinicopathological features. Results. We collected thirty gastric tissue samples from thirty patients with obesity. Blood tests, Electrocardiogram (ECG), esophagogastroduodenoscopy (EGDS) associated with a urea breath test, and chest X.R. were performed. A significant correlation between ATMs, MCPT, MVD, and BMI was found in GTO. Pearson t -test analysis was conducted (r ranged from 0.67 to 0.71; p -value < 0.05). Conclusions . These preliminary data suggest that ATMs, MCPT, and MVD related to BMI can play a role in both gastric tissue angiogenesis and inflammation inducing a tissue change that could lead to gastric inflammation or cancer diseases. |
