Characterization of Iron Oxide Nanotubes Obtained by Anodic Oxidation for Biomedical Applications-In Vitro Studies.

Autor: Rangel RCR; São Paulo State University (UNESP), School of Engineering, Ilha Solteira 15385-007, Brazil., Rangel ALR; São Paulo State University (UNESP), School of Engineering, Ilha Solteira 15385-007, Brazil., da Silva KB; São Paulo State University (UNESP), School of Engineering and Sciences, Guaratinguetá, São Paulo 01049-010, Brazil., Escada ALDA; São Paulo State University (UNESP), School of Engineering and Sciences, Guaratinguetá, São Paulo 01049-010, Brazil., Chaves JAM; Intelligent System Research Group, Faculty of Engineering, Corporación Universitaria Comfacauca-Unicomfacauca, Popayán 190003, Colombia., Maia FR; 3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal.; ICVS/3B's-PT Government Associated Laboratory, 4710-057 Guimarães, Portugal., Pina S; 3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal.; ICVS/3B's-PT Government Associated Laboratory, 4710-057 Guimarães, Portugal., Reis RL; 3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal.; ICVS/3B's-PT Government Associated Laboratory, 4710-057 Guimarães, Portugal., Oliveira JM; 3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal.; ICVS/3B's-PT Government Associated Laboratory, 4710-057 Guimarães, Portugal., Rosifini Alves AP; São Paulo State University (UNESP), School of Engineering and Sciences, Guaratinguetá, São Paulo 01049-010, Brazil.
Jazyk: angličtina
Zdroj: Materials (Basel, Switzerland) [Materials (Basel)] 2024 Jul 23; Vol. 17 (15). Date of Electronic Publication: 2024 Jul 23.
DOI: 10.3390/ma17153627
Abstrakt: To improve the biocompatibility and bioactivity of biodegradable iron-based materials, nanostructured surfaces formed by metal oxides offer a promising strategy for surface functionalization. To explore this potential, iron oxide nanotubes were synthesized on pure iron (Fe) using an anodic oxidation process (50 V-30 min, using an ethylene glycol solution containing 0.3% NH 4 F and 3% H 2 O, at a speed of 100 rpm). A nanotube layer composed mainly of α-Fe 2 O 3 with diameters between 60 and 70 nm was obtained. The effect of the Fe-oxide nanotube layer on cell viability and morphology was evaluated by in vitro studies using a human osteosarcoma cell line (SaOs-2 cells). The results showed that the presence of this layer did not harm the viability or morphology of the cells. Furthermore, cells cultured on anodized surfaces showed higher metabolic activity than those on non-anodized surfaces. This research suggests that growing a layer of Fe oxide nanotubes on pure Fe is a promising method for functionalizing and improving the cytocompatibility of iron substrates. This opens up new opportunities for biomedical applications, including the development of cardiovascular stents or osteosynthesis implants.
Databáze: MEDLINE
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