| Autor: |
Nešić MD; Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia., Nešić MS; Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia., Dimitrijević MŽ; Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia., Radulović NS; Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia. |
| Abstrakt: |
This study explores the chemical composition of essential oils from two Serbian Bupleurum species (Apiaceae), Bupleurum praealtum L. and Bupleurum affine L., traditionally recognized in Chinese medicine for their therapeutic potential but less studied for their essential oils. Through GC-MS analysis, we identified 230 constituents, revealing distinct profiles between the species. Perillyl 2-methylbutanoate was identified in B. affine oil for the first time, confirmed using synthetic approaches and characterized by advanced spectroscopic techniques, including two-dimensional NMR and spin-simulation of 1 H NMR spectra. Additionally, new natural compounds, including tentatively identified 4-decyl acetate and 4-undecyl acetate, were discovered. The study also reports five stereoisomeric esters of tetradeca-5,7,9,11-tetraen-1-ol. These findings significantly contribute to the understanding of the phytochemical diversity within the genus Bupleurum and underscore potential differences in ecological adaptations or biosynthetic pathways among species. |
