Reducing Capillary Leak Syndrome Mortality in Extremely Premature Infants: A Pilot Investigation.

Autor:	Boly TJ; Department of Pediatrics, The University of Iowa, Iowa City, IA, USA.; Iowa Inflammation Program, The University of Iowa, Iowa City, IA, USA., Lozano-Chinga MM; Department of Internal Medicine, The University of Iowa, Iowa City, IA, USA.; College of Medicine, The University of Arizona, Phoenix, AZ, USA.; Division of Pulmonology, Department of Pediatrics, Phoenix Children's Hospital, Phoenix, AZ, USA., Reyes-Hernandez ME; Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA., Elgin TG; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA., Ballas Z; Department of Internal Medicine, The University of Iowa, Iowa City, IA, USA., Bermick JR; Department of Pediatrics, The University of Iowa, Iowa City, IA, USA.; Iowa Inflammation Program, The University of Iowa, Iowa City, IA, USA.
Jazyk:	angličtina
Zdroj:	Clinical pediatrics [Clin Pediatr (Phila)] 2024 Aug 09, pp. 99228241272037. Date of Electronic Publication: 2024 Aug 09.
DOI:	10.1177/00099228241272037
Abstrakt:	Neonatal capillary leak syndrome (CLS) is a rare, but life-threatening condition following neonatal sepsis or inflammatory injury. The objective of this study was to describe a standardized treatment approach for CLS that improves mortality and neonatal outcomes. A retrospective cohort study of 10 infants born at 22 to 26 weeks of gestation who developed CLS following a significant inflammatory insult was performed. Time to diagnosis and treatment approaches over 2 epochs were recorded and described. In epoch 2, with increased clinical awareness of CLS and implementation of a standardized treatment approach, there was a non-statistically significant decrease in the time to treatment with a significant decrease in mortality. An early targeted treatment approach for neonatal CLS can decrease mortality rates in this highly morbid condition. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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