B cell senescence promotes age-related changes in oral microbiota.

Autor: Mizuno H; Department of Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Kawamoto S; Department of Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Uemura K; Department of Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Park JH; Department of Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Hori N; Department of Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Okumura Y; Department of Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Konishi Y; Department of Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Hara E; Department of Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.; Laboratory of Aging Biology, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.
Jazyk: angličtina
Zdroj: Aging cell [Aging Cell] 2024 Dec; Vol. 23 (12), pp. e14304. Date of Electronic Publication: 2024 Aug 09.
DOI: 10.1111/acel.14304
Abstrakt: In recent years, there has been increasing attention towards understanding the relationship between age-related alterations in the oral microbiota and age-associated diseases, with reports emphasizing the significance of maintaining a balanced oral microbiota for host health. However, the precise mechanisms underlying age-related changes in the oral microbiota remain elusive. We recently reported that cellular senescence of ileal germinal center (GC) B cells, triggered by the persistent presence of commensal bacteria, results in diminished IgA production with aging and subsequent alterations in the gut microbiota. Consequently, we hypothesize that a similar phenomenon may occur in the oral cavity, potentially contributing to age-related changes in the oral microbiota. Examination of p16-luc mice, wherein the expression of the senescent cell marker p16 INK4a can be visualized, raised under specific pathogen-free (SPF) or germ-free (GF) conditions, indicated that, unlike ileal GC B cells, the accumulation of senescent cells in GC B cells of cervical lymph nodes increases with age regardless of the presence of commensal bacteria. Furthermore, longitudinal studies utilizing the same individual mice throughout their lifespan revealed concurrent age-related alterations in the composition of the oral microbiota and a decline in salivary IgA secretion. Further investigation involving Rag1 -/- mice transplanted with B cells from wild-type or p16 INK4a and p21 Waf1/Cip1 -double knockout mice unveiled that B cell senescence leads to reduced IgA secretion and alteration of the oral microbiota. These findings advance our understanding of the mechanism of age-associated changes in the oral microbiota and open up possibilities of their control.
(© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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