Influence of Some Heterocyclic, Cyclic, and Nitrogen-Containing Compounds on Oxidative Deamination of Polyamines in a Cell-Free Test System.

Autor: Syatkin SP; V. A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, RUDN University, Moscow, Russia. syata@mail.ru., Blagonravov ML; V. A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, RUDN University, Moscow, Russia., Hilal A; V. A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, RUDN University, Moscow, Russia., Sungrapova KY; V. A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, RUDN University, Moscow, Russia., Sokuev RI; V. A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, RUDN University, Moscow, Russia., Korzun IA; V. A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, RUDN University, Moscow, Russia., Goryachev VA; V. A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, RUDN University, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Jul; Vol. 177 (3), pp. 307-312. Date of Electronic Publication: 2024 Aug 10.
DOI: 10.1007/s10517-024-06179-9
Abstrakt: We studied the effects of some nitrogen-containing, heterocyclic, and cyclic compounds on the rate of oxidative deamination of polyamines and putrescine in tissues with a high proliferation rate. For this purpose, the specific activities of the main enzymes of polyamine oxidative degradation - spermine oxidase (SMO), polyamine oxidase (PAO), and diamine oxidase (DAO) were determined using a cell-free test system from regenerating rat liver. The compounds methyl 2-(5-formylfuran-2-yl)benzoate and 2,7-bis-[2-(diethylamino)ethoxy]-9H-fluoren-9-one (and in the form of dihydrochloride) showed mainly activating effect on oxidative degradation of putrescine, spermidine, and spermine, which indirectly indicates their antiproliferative effect. Nitrogen-free compounds inhibited this process, thus exhibiting potentially carcinogenic properties. Correlations were calculated for activity of DAO, PAO, and SMO with 5 topological indices: Wiener (W), Rouvray (R), Balaban (J) in the Trinaistich modification, detour (Ip), and electropy (Ie). The highest dependence was noted for DAO and the Balaban index (R=-0.55), for PAO and the detour index (R=0.78), and for SMO and the electropy index (R=0.53). The remaining dependencies showed insignificant correlation strength.
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Databáze: MEDLINE
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